ROS1 - ROS proto-oncogene 1, receptor tyrosine kinase Gene

Species: Canis lupus familiaris (sub-species: familiaris)

Gene Type: protein coding
Gene ID: 484098

About ROS1

Primary_assembly 1: 57,737,370-57,859,071 reverse strand.ROS_Cfam_1.0:CM025100.1

This gene has 3 transcripts (splice variants), 125 orthologues and 54 paralogues.

ROS1 Products (10)

mRNA Protein Name
XM_038654734.1 XP_038510662.1 proto-oncogene tyrosine-protein kinase ROS isoform X4
XM_038654730.1 XP_038510658.1 proto-oncogene tyrosine-protein kinase ROS isoform X1
XM_038654731.1 XP_038510659.1 proto-oncogene tyrosine-protein kinase ROS isoform X1
XM_038654733.1 XP_038510661.1 proto-oncogene tyrosine-protein kinase ROS isoform X3
XM_038654732.1 XP_038510660.1 proto-oncogene tyrosine-protein kinase ROS isoform X2
XM_038654732.1 XP_038510660.1 proto-oncogene tyrosine-protein kinase ROS isoform X2
XM_038654733.1 XP_038510661.1 proto-oncogene tyrosine-protein kinase ROS isoform X3
XM_038654730.1 XP_038510658.1 proto-oncogene tyrosine-protein kinase ROS isoform X1
XM_038654731.1 XP_038510659.1 proto-oncogene tyrosine-protein kinase ROS isoform X1
XM_038654734.1 XP_038510662.1 proto-oncogene tyrosine-protein kinase ROS isoform X4

ROS1 Protein Structure

FN3

FN3: smart00060 (110 - 177)

FN3

FN3: cd00063 (205 - 289)

FN3

FN3: cd00063 (566 - 662)

FN3

FN3: cd00063 (955 - 1022)

FN3

FN3: cd00063 (1035 - 1141)

FN3

FN3: cd00063 (1651 - 1742)

FN3

FN3: cd00063 (1747 - 1836)

PTKc_c-ros

PTKc_c-ros: cd05044 (1944 - 2211)

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  • 2000
  • 2343 a.a.
Protein Preferred Names Protein Names

proto-oncogene tyrosine-protein kinase ROS

  • c-ros oncogene 1 , receptor tyrosine kinase

  • v-ros UR2 sarcoma oncogene homolog 1

  • v-ros UR2 sarcoma virus oncogene homolog 1

Related Agents

  • Approval
  • Clinical Phase
  • Pre-clinical Phase

Approval

Bioactive Molecules (9)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-50878 Crizotinib Inhibitor 99.97% Yes
HY-12215 Lorlatinib 99.99% Yes
HY-W015913 Pyruvic acid sodium Inhibitor 99.86% Yes
HY-12678 Entrectinib 99.26% Yes
HY-103022 Repotrectinib Inhibitor 99.95% Unkown
HY-50878A Crizotinib hydrochloride 99.86% Yes
HY-145574 Iruplinalkib Inhibitor 99.62% Unkown
HY-12215R Lorlatinib (Standard) 99.92% Unkown
HY-50878B Crizotinib acetate Inhibitor / Unkown

Clinical Phase

Bioactive Molecules (7)
Cat. No. Product Name Effect
Purity Phase
HY-131003A Taletrectinib free base Inhibitor / Phase 3
HY-176942 JYP0322 Inhibitor / Phase 3
HY-131003 Taletrectinib Inhibitor 99.63% Phase 2
HY-152292 Zidesamtinib Inhibitor 99.78% Phase 2
HY-15514 Merestinib Inhibitor 99.99% Phase 2
HY-15514A Merestinib dihydrochloride Inhibitor 99.36% Phase 2
HY-155163 APG-2449 Inhibitor 98.93% Phase 1

Pre-clinical Phase

Bioactive Molecules (55)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-N0578 Apigenin 7-glucoside 98.98% Unkown
HY-W015913S Pyruvic acid-13C3 sodium Inhibitor 99.7% Unkown
HY-122311 Orniplabin Inhibitor 98% Unkown
HY-159147 SIA​​IS039 99.68% Unkown
HY-12678S1 Entrectinib-d8 99.82% Unkown
HY-N7798 Pennogenin 99.90% Unkown
HY-B1106 Tetrahydroxyquinone 98.0% Unkown
HY-50878S Crizotinib-d5 99.60% Unkown
HY-112801 F-1 Inhibitor 98.03% Unkown
HY-12678S Entrectinib-d4 Inhibitor / Unkown
HY-B1106A Tetrahydroxyquinone monohydrate 97.0% Unkown
HY-N10144 Shinpterocarpin Inhibitor / Unkown
HY-N1306 Sideroxylin / Unkown
HY-N2693 6,8-Diprenylorobol 98.40% Unkown
HY-W015913R Pyruvic acid sodium (Standard) Inhibitor 99.98% Unkown
HY-161358 FAK-IN-20 / Unkown
HY-111416 WY-135 Inhibitor / Unkown
HY-135509 Lorlatinib acetate / Unkown
HY-115541 BRD4-IN-41 Inhibitor / Unkown
HY-117420 CM764 Activator / Unkown
HY-120387 SMU-B Inhibitor / Unkown
HY-122311A Bis(2R,3R)-Orniplabin 95.0% Unkown
HY-123454 SKF1 / Unkown
HY-130794 ALK/ROS1-IN-1 Inhibitor / Unkown
HY-144697 p38 MAPK-IN-3 / Unkown
HY-147795 Nampt-IN-8 / Unkown
HY-150974 ROS1-IN-1 Inhibitor / Unkown
HY-153743 Protein kinase inhibitor 4 Inhibitor / Unkown
HY-155178 Antiproliferative agent-34 Inhibitor / Unkown
HY-156360 Xanthine oxidase-IN-12 Inhibitor / Unkown
HY-157391 ALK/ROS1-IN-3 Inhibitor / Unkown
HY-157437 AChE/BChE-IN-16 Inhibitor / Unkown
HY-158016 Antiproliferative agent-49 / Unkown
HY-161966 VEGFR-2-IN-52 / Unkown
HY-161975 ROS1-IN-2 Inhibitor / Unkown
HY-162311 Anticancer agent 194 / Unkown
HY-163862 PPARα agonist 3 / Unkown
HY-170418 ALK/ROS1-IN-5 / Unkown
HY-178391 SMU-037 / Unkown
HY-179052 Apoptosis inducer 50 / Unkown
HY-179527 LIG48 Inhibitor / Unkown
HY-50878AS Crizotinib-d9 hydrochloride / Unkown
HY-N11887 Linocinnamarin Inhibitor 99.14% Unkown
HY-RS12135 ROS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12136 Ros1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS12137 ROS1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-160172 ALK/ROS1-IN-4 Inhibitor / Unkown
HY-160172A ALK/ROS1-IN-4 hydrate Inhibitor / Unkown
HY-162488 Laccase-IN-3 Inhibitor / Unkown
HY-179710 SET-12 / Unkown
HY-50878S1 Crizotinib-d8 / Unkown
HY-50878S2 Crizotinib-d9 / Unkown
HY-B0847S Propiconazole-d7 / Unkown
HY-W587743 N1-Acetyl-5-methoxykynuramine hydrochloride Inhibitor / Unkown
HY-W927359 Fluorescein hydrazide (3,6-Dihydroxyxanthane) / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens ROS1 NCBI NCBI:6098