2. Protein Tyrosine Kinase/RTK
  3. ROS Kinase
  4. LIG48

LIG48 is ROS1 kinase domain and its mutant (G2032R ROS1 kinase domain) inhibitor. LIG48 remains within the mutated and wild-type ROS1 kinase domains. LIG48 can be used for the study of non-small cell lung cancer.

For research use only. We do not sell to patients.

LIG48

LIG48 Chemical Structure

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LIG48 Related Antibodies

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Description

LIG48 is ROS1 kinase domain and its mutant (G2032R ROS1 kinase domain) inhibitor. LIG48 remains within the mutated and wild-type ROS1 kinase domains. LIG48 can be used for the study of non-small cell lung cancer[1].

In Vitro

LIG48 shows the highest binding affinity for wild-type ROS1 (-9.272 kcal/mol) and a binding affinity for G2032R mutant ROS1 of -8.9 kcal/mol[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

LIG48 Related Antibodies
Molecular Weight

451.48

Formula

C22H25N7O4
SMILES

O=C(CN1C=CC(N)=NC1=O)N(C=C2C[C@@H](C(N3CCC[C@H]3C(N)=O)=O)N)C4=C2C=CC=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LIG48 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LIG48LIG 48LIG-48ROS KinaseComputer-aided-drug-designCrizotinibMolecular dynamics simulationsDockingProtooncogene tyrosine-protein kinase ROSProtein simulationMACCSInhibitorinhibitorinhibit

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