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United States

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Cat. No.: HY-157391

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ALK/ROS1-IN-3

ALK/ROS1-IN-3 (compound C01) is a ROS1 and ALK dual inhibitor with IC₅₀s of 42.3 nM and 49.1 nM for ROS1^G2032R and ALK^G1202R, respectively.

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Formule: C₃₂H₃₂N₄O₂
Masse moléculaire:504.62

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

ALK/ROS1-IN-3 Chemical Structure

Stock

Quantité

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique

Description

ALK/ROS1-IN-3 (compound C01) is a ROS1 and ALK dual inhibitor with IC₅₀s of 42.3 nM and 49.1 nM for ROS1^G2032R and ALK^G1202R, respectively^[1].

Chemical Information

Masse moléculaire 504.62
Formule C₃₂H₃₂N₄O₂
SMILES

NC(N=CC(C1=CC2=C(NC(C23CCN(CC3)C)=O)C=C1)=C4)=C4O[C@H](C)C5=CC=CC=C5C6=CC=CC=C6
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Select Batch:

Pureté: 99.98%

Assay: 99.98%

ee.: 99.98%

Fiche technique (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Instruction de manipulation (2659 KB)

Références

[1]. Siming Liu, et al. Discovery of novel 2-aminopyridine derivatives as ROS1 and ALK dual inhibitors to combat drug-resistant mutants including ROS1G2032R and ALKG1202R. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2227779. [Content Brief]

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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