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Cat. No.: HY-157391

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ALK/ROS1-IN-3

ALK/ROS1-IN-3 (compound C01) is a ROS1 and ALK dual inhibitor with IC₅₀s of 42.3 nM and 49.1 nM for ROS1^G2032R and ALK^G1202R, respectively.

For research use only. We do not sell to patients.

Formula: C₃₂H₃₂N₄O₂
Molecular Weight:504.62

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

ALK/ROS1-IN-3 Chemical Structure

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity

Description

ALK/ROS1-IN-3 (compound C01) is a ROS1 and ALK dual inhibitor with IC₅₀s of 42.3 nM and 49.1 nM for ROS1^G2032R and ALK^G1202R, respectively^[1].

Chemical Information

Molecular Weight 504.62
Formula C₃₂H₃₂N₄O₂
SMILES

NC(N=CC(C1=CC2=C(NC(C23CCN(CC3)C)=O)C=C1)=C4)=C4O[C@H](C)C5=CC=CC=C5C6=CC=CC=C6
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Siming Liu, et al. Discovery of novel 2-aminopyridine derivatives as ROS1 and ALK dual inhibitors to combat drug-resistant mutants including ROS1G2032R and ALKG1202R. J Enzyme Inhib Med Chem. 2023 Dec;38(1):2227779. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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