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Cat. No.: HY-150974

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ROS1-IN-1

ROS1-IN-1 (Compound 31) is a potent and selective ROS1 kinase inhibitor with an IC₅₀ of 0.097 μM.

For research use only. We do not sell to patients.

CAS No.: 2883232-34-4
Formula: C₁₇H₁₅ClN₆S
Molecular Weight:370.86

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

ROS1-IN-1 Chemical Structure

CAS No.: 2883232-34-4

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

ROS1-IN-1 (Compound 31) is a potent and selective ROS1 kinase inhibitor with an IC₅₀ of 0.097 μM^[1].

IC₅₀ & Target

IC₅₀: 0.097 μM (ROS1)^[1]

In Vitro

ROS1-IN-1 (Compound 31) (1 μM) does not inhibit any other kinase at >50%, making it a truly selective starting point for optimization against ROS1^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2883232-34-4
Molecular Weight 370.86
Formula C₁₇H₁₅ClN₆S
SMILES

CC1=NC(N(CC2=CC=C(C(Cl)=C2)C#N)C)=NC(NC3=NC=CS3)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Petrović D, et al. Virtual Screening in the Cloud Identifies Potent and Selective ROS1 Kinase Inhibitors. J Chem Inf Model. 2022 Aug 3. [Content Brief]

Calculators

Molarity Calculator

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Dilution Calculator

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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