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Cat. No.: HY-147795

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Nampt-IN-8

Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC₅₀ of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS.

For research use only. We do not sell to patients.

CAS No.: 2453183-75-8
Formula: C₃₆H₃₅N₃O₄
Molecular Weight:573.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

Nampt-IN-8 Chemical Structure

CAS No.: 2453183-75-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC₅₀ of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS^[1].

IC₅₀ & Target

IC₅₀: 0.183 μM (NAMPT)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.15 μM Compound: 10d	Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by cell titer glo luminescent assay Antiproliferative activity against human A549 cells assessed as inhibition of cell growth incubated for 72 hrs by cell titer glo luminescent assay	[PMID: 35640078]
A549/TR	IC₅₀	11.82 μM Compound: 10d	Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with nicotinamide mononucleotide followed by compound addition and measured after 72 hrs by cell titer glo luminescent assay Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with nicotinamide mononucleotide followed by compound addition and measured after 72 hrs by cell titer glo luminescent assay	[PMID: 35640078]
A549/TR	IC₅₀	124.9 μM Compound: 10d	Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with nicotinamide mononucleotide, dicumarol, N-acetyl-L-cysteine followed by compound addition and measured after 72 hrs by cell titer glo luminesce Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with nicotinamide mononucleotide, dicumarol, N-acetyl-L-cysteine followed by compound addition and measured after 72 hrs by cell titer glo luminesce	[PMID: 35640078]
A549/TR	IC₅₀	14.48 μM Compound: 10d	Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with NQO1 inhibitor, dicumarol followed by compound addition and measured after for 72 hrs by cell titer glo luminescent assay Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with NQO1 inhibitor, dicumarol followed by compound addition and measured after for 72 hrs by cell titer glo luminescent assay	[PMID: 35640078]
A549/TR	IC₅₀	4.1 μM Compound: 10d	Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth measured after 72 hrs by cell titer glo luminescent assay Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth measured after 72 hrs by cell titer glo luminescent assay	[PMID: 35640078]
A549/TR	IC₅₀	45.29 μM Compound: 10d	Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with N-acetyl-L-cysteine followed by compound addition and measured after 72 hrs by cell titer glo luminescent assay Antiproliferative activity against human A549/Taxol cells assessed as inhibition of cell growth pretreated with N-acetyl-L-cysteine followed by compound addition and measured after 72 hrs by cell titer glo luminescent assay	[PMID: 35640078]
L02	IC₅₀	120.4 μM Compound: 10d	Antiproliferative activity against human L02 cells assessed as inhibition of cell growth measured after 72 hrs by cell titer glo luminescent assay Antiproliferative activity against human L02 cells assessed as inhibition of cell growth measured after 72 hrs by cell titer glo luminescent assay	[PMID: 35640078]

In Vitro

Nampt-IN-8 (Compound 10d) shows antiproliferative activity with an IC₅₀ of 1.15 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Nampt-IN-8 (Compound 10d) (0-20 mg/kg) substantially inhibits the growth of A549/taxol xenograft tumors in vivo with no significant toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2453183-75-8
Molecular Weight 573.68
Formula C₃₆H₃₅N₃O₄
SMILES

O=C1C2=C(CCCC3(C)C)C3=CC=C2C4=C(C1=O)C(C)=C(O4)CNC5=CC=C(C=C5)CCNC(/C=C/C6=CN=CC=C6)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (266 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Zhang K, et al. Discovery of Small Molecules Simultaneously Targeting NAD(P)H:Quinone Oxidoreductase 1 and Nicotinamide Phosphoribosyltransferase: Treatment of Drug-Resistant Non-small-Cell Lung Cancer. J Med Chem. 2022 Jun 9;65(11):7746-7769. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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