2453183-75-8
2453183-75-8
Chemical Structure
Nampt-IN-8
- CAS No.: 2453183-75-8
- Formula:C36H35N3O4
- Molecular Weight:573.68
IUPAC Name: (E)-3-(pyridin-3-yl)-N-(4-(((1,6,6-trimethyl-10,11-dioxo-6,7,8,9,10,11-hexahydrophenanthro[1,2-b]furan-2-yl)methyl)amino)phenethyl)acrylamide
InChIKey: HLJAUZKCZAINLG-XNTDXEJSSA-N
SMILES: O=C1C2=C(CCCC3(C)C)C3=CC=C2C4=C(C1=O)C(C)=C(O4)CNC5=CC=C(C=C5)CCNC(/C=C/C6=CN=CC=C6)=O
Biological Activity: Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC50 of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS[1].
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Nampt-IN-8 | Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC50 of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS. | |||||||||||||||||||||
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