RXFP3 - relaxin family peptide receptor 3 Gene

Also Known as SALPR; RLN3R1; RXFPR3; GPCR135

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 51289

About RXFP3

Cytogenetic location: 5p13.2 Genomic coordinates (GRCh38): 5:33,936,386-33,938,918 (from NCBI)

This gene has 1 transcript (splice variant), 1 gene allele, 101 orthologues and 7 paralogues.

Summary

Predicted to enable G protein-coupled peptide receptor activity. Involved in positive regulation of cytokinesis. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

RXFP3 Products (1)

mRNA Protein Name
NM_016568.3 NP_057652.1 relaxin-3 receptor 1

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence References Source
involved in positive regulation of cytokinesis IMP
IMP: Inferred from mutant phenotype
22888021 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RXFP3 Protein Structure

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (98 - 196)

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (214 - 389)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 469 a.a.
Protein Preferred Names Protein Names

relaxin-3 receptor 1

  • G-protein coupled receptor GPCR135

Related Diseases

Diseases Alias
Schizotypal Personality Disorder

  • Schizotypal Personality
Chromosome 5p13 Duplication Syndrome

  • 5p13 Microduplication Syndrome

  • Trisomy 5p13

  • Dup(5)(P13)
Chondroid Chordoma
Radiation Cystitis

  • Irradiation Cystitis
Chordoid Meningioma

  • Meningioma, Chordoid
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (9)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-150700 RLX-33 Modulator 99.79% Unkown
HY-145278 RXFP3/4 agonist 2 99.75% Unkown
HY-145279 RXFP3 agonist 1 / Unkown
HY-P10687 H3B10-27(13/17αF) / Unkown
HY-P11246 A13:B7-24-GG Agonist / Unkown
HY-RS12359 RXFP3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-111583 RXFP3/4 agonist 1 / Unkown
HY-RS19034 Rxfp3 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25523 Rxfp3 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992108 Efadirelaxin alfa Activator / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus RXFP3 MGD MGI:2441827
Felis catus RXFP3 VGNC VGNC:64833
Rattus norvegicus RXFP3 RGD RGD:1311550
Bos taurus RXFP3 VGNC VGNC:58407
Macaca mulatta RXFP3 VGNC VGNC:110436
Others RXFP3 NCBI