RXFP3/4 agonist 1
RXFP3/4 agonist 1 is an agonist of relaxin family peptide 3/4 receptor (RXFP3/4), with EC50s of 82/2 nM, respectivley. RXFP3/4 agonist 1 increases food intake in rats.
For research use only. We do not sell to patients.
- CAS No.: 2351104-40-8
- Formula: C20H22ClN5O
- Molecular Weight:383.87
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
EC50: 82 nM (RXFP3), 2 nM (RXFP4)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| U2OS | EC50 |
4.9 μM
Compound: 4
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Agonist activity at human RXFP3/4 in human U2OS cells assessed as induction of beta-arrestin recruitment incubated for 1 hr by chemiluminescence based PathHunter beta-arrestin assay
Agonist activity at human RXFP3/4 in human U2OS cells assessed as induction of beta-arrestin recruitment incubated for 1 hr by chemiluminescence based PathHunter beta-arrestin assay
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[PMID: 30824200] |
RXFP3/4 agonist 1 (Compound 4) inhibits orskolin-stimulated cAMP accumulation in CHO-K1 cells stably overexpressing RXFP3 and RXFP4, with EC50s of 12.8 and 1.6 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2351104-40-8
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Molecular Weight 383.87
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Formula C20H22ClN5O
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SMILES
CCC1=C(NC=C2/C=N/NC(NCCC3=CC=C(Cl)C=C3)=N)C2=CC(O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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