Pla2g6 - phospholipase A2, group VI Gene

Also Known as iPLA2; PNPLA9; iPLA2beta; iPLA(2)beta

Species: Mus musculus

Gene Type: protein coding
Gene ID: 53357

Summary

Enables calcium-independent Phospholipase A2 activity; palmitoyl-CoA hydrolase activity; and serine hydrolase activity. Involved in positive regulation of Insulin secretion involved in cellular response to glucose stimulus. Predicted to be located in centriolar satellite; cytosol; and extracellular space. Predicted to be active in mitochondrion. Is expressed in 1st branchial arch maxillary component; olfactory placode; otic pit; and trunk somite. Used to study neurodegeneration with brain iron accumulation 2a. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (Phospholipase A2 group VI). [provided by Alliance of Genome Resources, Apr 2022]

Pla2g6 Products (4)

mRNA Protein Name
NM_001199023.1 NP_001185952.1 85/88 kDa calcium-independent phospholipase A2 isoform 2
NM_001199024.1 NP_001185953.1 85/88 kDa calcium-independent phospholipase A2 isoform 1
NM_001199025.1 NP_001185954.1 85/88 kDa calcium-independent phospholipase A2 isoform 1
NM_016915.4 NP_058611.1 85/88 kDa calcium-independent phospholipase A2 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence References Source
enables calcium-independent phospholipase A2 activity IMP
IMP: Inferred from mutant phenotype
17895289 MGI
enables long-chain fatty acyl-CoA hydrolase activity IMP
IMP: Inferred from mutant phenotype
18937505 MGI
enables serine hydrolase activity IDA
IDA: Inferred from direct assay
16818490 MGI
Biological Process GO Annotation Evidence References Source
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: Inferred from mutant phenotype
17895289 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

85/88 kDa calcium-independent phospholipase A2

  • 2-lysophosphatidylcholine acylhydrolase

  • 85 kDa calcium-independent phospholipase A2

  • GVI PLA2

  • caI-PLA2

  • group VI phospholipase A2

  • iPLA2-beta

  • intracellular membrane-associated calcium-independent phospholipase A2 beta

  • palmitoyl-CoA hydrolase

  • patatin-

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-18705 Azoramide 99.57% Unkown
HY-122949 Momordicine I 97.0% Unkown
HY-RS10633 PLA2G6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pla2g6 NCBI NCBI:8398