ETAA1 - ETAA1 activator of ATR kinase Gene

Also Known as ETAA16

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 54465

About ETAA1

Cytogenetic location: 2p14 Genomic coordinates (GRCh38): 2:67,397,333-67,412,089 (from NCBI)

This gene has 4 transcripts (splice variants) and 230 orthologues. Ubiquitous expression in thyroid (RPKM 6.6), endometrium (RPKM 6.0) and 25 other tissues.

Summary

Enables protein serine/threonine kinase activator activity. Involved in several processes, including positive regulation of protein serine/threonine kinase activity; regulation of DNA damage checkpoint; and replication fork processing. Located in cytosol; nuclear replication fork; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

ETAA1 Products (1)

mRNA Protein Name
NM_019002.4 NP_061875.2 ewing's tumor-associated antigen 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Referencias Source
enables protein binding IPI
IPI: Inferred from physical interaction
27723717 GOA
enables protein serine/threonine kinase activator activity IDA
IDA: Inferred from direct assay
27723717 GOA
Biological Process GO Annotation Evidence Referencias Source
involved in DNA damage response IDA
IDA: Inferred from direct assay
27723717 GOA
involved in mitotic G2/M transition checkpoint IDA
IDA: Inferred from direct assay
30139873 GOA
involved in positive regulation of protein serine/threonine kinase activity IDA
IDA: Inferred from direct assay
27723717 GOA
involved in regulation of DNA damage checkpoint IDA
IDA: Inferred from direct assay
27723717 GOA
involved in replication fork processing IDA
IDA: Inferred from direct assay
27723717 GOA
Cellular Component GO Annotation Evidence Referencias Source
located in nuclear replication fork IDA
IDA: Inferred from direct assay
27723717 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ETAA1 Protein Structure

ETAA1

ETAA1: Ewing's tumour-associated antigen 1 homologue (76 - 648)

ETAA1

ETAA1: Ewing's tumour-associated antigen 1 homologue (648 - 913)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 926 a.a.
Protein Preferred Names Protein Names

ewing's tumor-associated antigen 1

  • ETAA1, ATR kinase activator

ETAA1 Antibodies

Referencia número Nombre del producto Aplicación Reactivity
HY-P83036 ETAA1 Antibody (YA2781) WB Human
HY-P83036A ETAA1 Antibody (YA2781)(PBS only) WB Human

Related Diseases

Diseases Alias
Immunodeficiency 26

  • Severe Combined Immunodeficiency Due To Dna-Pkcs Deficiency

  • Scid Due To Dna-Pkcs Deficiency

  • Imd26

  • Immunodeficiency 26, With Or Without Neurologic Abnormalities
Restless Legs Syndrome

  • Wed

  • Willis-Ekbom Disease

  • Restless Leg Syndrome

  • Ekbom Syndrome

  • Wittmaack-Ekbom Syndrome

  • Willis Ekbom Disease

  • Ekbom'S Syndrome

  • Rls

  • Restless Legs

  • Restless Legs Syndrome, Susceptibility To
Seckel Syndrome

  • Microcephalic Primordial Dwarfism

  • Bird-Headed Dwarfism

  • Harper'S Syndrome

  • Virchow-Seckel Dwarfism

  • Nanocephalic Dwarfism

  • Sckl

  • Seckel-Type Dwarfism
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Referencia número Nombre del producto
Efecto
Pureza
Rare Diseases
HY-RS04550 ETAA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22495 Etaa1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29018 Etaa1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus ETAA1 RGD RGD:1587340
Macaca mulatta ETAA1 VGNC VGNC:106157
Bos taurus ETAA1 VGNC VGNC:28616
Canis familiaris ETAA1 VGNC VGNC:40486
Felis catus ETAA1 VGNC VGNC:61974
Mus musculus ETAA1 MGD MGI:1915395
Others ETAA1 NCBI