PPP1CC - protein phosphatase 1 catalytic subunit gamma Gene
Also Known as PP1C; PP-1G; PPP1G
Species: Homo sapiens
About PPP1CC
This gene has 11 transcripts (splice variants), 231 orthologues and 12 paralogues. Ubiquitous expression in duodenum (RPKM 77.6), small intestine (RPKM 62.4) and 25 other tissues.
Summary
The protein encoded by this gene belongs to the protein Phosphatase family, PP1 subfamily. PP1 is an ubiquitous serine/threonine Phosphatase that regulates many cellular processes, including cell division. It is expressed in mammalian cells as three closely related isoforms, alpha, beta/delta and gamma, which have distinct localization patterns. This gene encodes the gamma isozyme. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
PPP1CC Products (2)
| mRNA | Protein | Name |
|---|---|---|
| NM_001244974.2 | NP_001231903.1 | serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 2 |
| NM_002710.4 | NP_002701.1 | serine/threonine-protein phosphatase PP1-gamma catalytic subunit isoform 1 |
PPP1CC Protein Structure
Metallophos: Calcineurin-like phosphoesterase (59 - 250)
- 0
- 100
- 200
- 300
- 323 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
serine/threonine-protein phosphatase PP1-gamma catalytic subunit |
|
PPP1CC Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
PPP1CC | P36873 | KNL1 | Homo sapiens | Q8NG31 | 33961781 | |
|
Intra
|
PPP1CC | P36873 | TP53BP2 | Homo sapiens | Q13625-3 | 25416956 | |
|
Intra
|
PPP1CC | P36873 | TP53BP2 | Homo sapiens | Q13625-3 | 25416956 | |
|
Intra
|
PPP1CC | P36873 | TP53BP2 | Homo sapiens | Q13625-3 | 25416956 | |
|
Intra
|
PPP1CC | P36873 | PPP1R7 | Homo sapiens | Q15435 | 24366813 | |
|
Intra
|
PPP1CC | P36873 | PPP1R7 | Homo sapiens | Q15435 | 33961781 | |
|
Intra
|
PPP1CC | P36873 | PPP1R7 | Homo sapiens | Q15435 | 23414517 | |
|
Intra
|
PPP1CC | P36873 | PPP1R7 | Homo sapiens | Q15435 | 28330616 | |
|
Intra
|
PPP1CC | P36873 | PPP1R7 | Homo sapiens | Q15435 | 28330616 | |
|
Intra
|
PPP1CC | P36873 | PPP1R2B | Homo sapiens | Q6NXS1 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | PPP1R11 | Homo sapiens | O60927 | 33961781 | |
|
Intra
|
PPP1CC | P36873 | PPP1R11 | Homo sapiens | O60927 | 24366813 | |
|
Intra
|
PPP1CC | P36873 | PPP1R11 | Homo sapiens | O60927 | 28330616 | |
|
Intra
|
PPP1CC | P36873 | PPP1R11 | Homo sapiens | O60927 | 28330616 | |
|
Intra
|
PPP1CC | P36873 | PPP1R2 | Homo sapiens | P41236 | 28330616 | |
|
Intra
|
PPP1CC | P36873 | PPP1R2 | Homo sapiens | P41236 | 28330616 | |
|
Intra
|
PPP1CC | P36873 | PPP1R2 | Homo sapiens | P41236 | 24366813 | |
|
Intra
|
PPP1CC | P36873 | PPP1R2 | Homo sapiens | P41236 | 12761178 | |
|
Intra
|
PPP1CC | P36873 | PPP1R2 | Homo sapiens | P41236 | 33961781 | |
|
Intra
|
PPP1CC | P36873 | PPP1R2 | Homo sapiens | P41236 | 26496610 | |
|
Intra
|
PPP1CC | P36873 | TP53BP2 | Homo sapiens | Q05BL1 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | TP53BP2 | Homo sapiens | Q05BL1 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | TP53BP2 | Homo sapiens | Q05BL1 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | TPRN | Homo sapiens | Q4KMQ1-2 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | TPRN | Homo sapiens | Q4KMQ1-2 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | TPRN | Homo sapiens | Q4KMQ1-2 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | SAXO4 | Homo sapiens | Q7Z5V6-2 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | NRAC | Homo sapiens | Q8N912 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | PPP1R8 | Homo sapiens | Q12972-2 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | PPP1R8 | Homo sapiens | Q12972-2 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | PPP1R8 | Homo sapiens | Q12972-2 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | URI1 | Homo sapiens | O94763-1 | 27505673 | |
|
Intra
|
PPP1CC | P36873 | AATK | Homo sapiens | Q6ZMQ8 | 28065597 | |
|
Intra
|
PPP1CC | P36873 | LMTK2 | Homo sapiens | Q8IWU2 | 33961781 | |
|
Intra
|
PPP1CC | P36873 | LMTK2 | Homo sapiens | Q8IWU2 | 24366813 | |
|
Intra
|
PPP1CC | P36873 | LMTK2 | Homo sapiens | Q8IWU2 | 28065597 | |
|
Intra
|
PPP1CC | P36873 | LMTK2 | Homo sapiens | Q8IWU2 | 28330616 | |
|
Intra
|
PPP1CC | P36873 | LMTK2 | Homo sapiens | Q8IWU2 | 28330616 | |
|
Intra
|
PPP1CC | P36873 | LMTK2 | Homo sapiens | Q8IWU2 | 26496610 | |
|
Intra
|
PPP1CC | P36873 | PPP1R3C | Homo sapiens | Q9UQK1 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | PPP1R3C | Homo sapiens | Q9UQK1 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | PPP1R3C | Homo sapiens | Q9UQK1 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | PPP1R15B | Homo sapiens | Q5SWA1 | 28330616 | |
|
Intra
|
PPP1CC | P36873 | PPP1R15B | Homo sapiens | Q5SWA1 | 28330616 | |
|
Intra
|
PPP1CC | P36873 | PPP1R15B | Homo sapiens | Q5SWA1 | 33961781 | |
|
Intra
|
PPP1CC | P36873 | ZFYVE9 | Homo sapiens | O95405 | 33961781 | |
|
Intra
|
PPP1CC | P36873 | ZFYVE9 | Homo sapiens | O95405 | 25416956 | |
|
Intra
|
PPP1CC | P36873 | ZFYVE9 | Homo sapiens | O95405 | 25416956 | |
|
Intra
|
PPP1CC | P36873 | ZFYVE9 | Homo sapiens | O95405 | 24366813 | |
|
Intra
|
PPP1CC | P36873 | PPP1R9B | Homo sapiens | Q96SB3 | 28330616 | |
|
Intra
|
PPP1CC | P36873 | PPP1R9B | Homo sapiens | Q96SB3 | 25785436 | |
|
Intra
|
PPP1CC | P36873 | PPP1R9B | Homo sapiens | Q96SB3 | 33961781 | |
|
Intra
|
PPP1CC | P36873 | PPP1R9B | Homo sapiens | Q96SB3 | 24366813 | |
|
Intra
|
PPP1CC | P36873 | PPP1R9B | Homo sapiens | Q96SB3 | 26496610 | |
|
Intra
|
PPP1CC | P36873 | PPP1R9B | Homo sapiens | Q96SB3 | 28330616 | |
|
Intra
|
PPP1CC | P36873 | URI1 | Homo sapiens | O94763 | 27505673 | |
|
Intra
|
PPP1CC | P36873 | URI1 | Homo sapiens | O94763 | 33961781 | |
|
Intra
|
PPP1CC | P36873 | URI1 | Homo sapiens | O94763 | 26496610 | |
|
Intra
|
PPP1CC | P36873 | URI1 | Homo sapiens | O94763 | 21397856 | |
|
Intra
|
PPP1CC | P36873 | URI1 | Homo sapiens | O94763 | 28330616 | |
|
Intra
|
PPP1CC | P36873 | URI1 | Homo sapiens | O94763 | 24366813 | |
|
Intra
|
PPP1CC | P36873 | URI1 | Homo sapiens | O94763 | 28330616 | |
|
Intra
|
PPP1CC | P36873 | RRP1B | Homo sapiens | Q14684 | 33961781 | |
|
Intra
|
PPP1CC | P36873 | RRP1B | Homo sapiens | Q14684 | 24366813 | |
|
Intra
|
PPP1CC | P36873 | RRP1B | Homo sapiens | Q14684 | 20926688 | |
|
Intra
|
PPP1CC | P36873 | RRP1B | Homo sapiens | Q14684 | 28330616 | |
|
Intra
|
PPP1CC | P36873 | RRP1B | Homo sapiens | Q14684 | 28330616 | |
|
Intra
|
PPP1CC | P36873 | RRP1B | Homo sapiens | Q14684 | 20926688 | |
|
Intra
|
PPP1CC | P36873 | PPP1R3B | Homo sapiens | Q86XI6 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | PPP1R3B | Homo sapiens | Q86XI6 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | PPP1R3B | Homo sapiens | Q86XI6 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | CSRNP1 | Homo sapiens | Q96S65 | 25416956 | |
|
Intra
|
PPP1CC | P36873 | CSRNP1 | Homo sapiens | Q96S65 | 25416956 | |
|
Intra
|
PPP1CC | P36873 | CSRNP2 | Homo sapiens | Q9H175 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | CSRNP2 | Homo sapiens | Q9H175 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | CSRNP2 | Homo sapiens | Q9H175 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | CSRNP2 | Homo sapiens | Q9H175 | 33961781 | |
|
Intra
|
PPP1CC | P36873 | CSRNP2 | Homo sapiens | Q9H175 | 29892012 | |
|
Intra
|
PPP1CC | P36873 | OGT | Homo sapiens | O15294 | 27505673 | |
|
Intra
|
PPP1CC | P36873 | PPP1R16A | Homo sapiens | Q96I34 | 32296183 | |
|
Intra
|
PPP1CC | P36873 | CD2BP2 | Homo sapiens | O95400 | 25416956 | |
|
Intra
|
PPP1CC | P36873 | CD2BP2 | Homo sapiens | O95400 | 25416956 | |
|
Intra
|
PPP1CC | P36873 | TP53BP2 | Homo sapiens | Q13625 | 33961781 | |
|
Intra
|
PPP1CC | P36873 | TP53BP2 | Homo sapiens | Q13625 | 18448430 | |
|
Intra
|
PPP1CC | P36873 | TP53BP2 | Homo sapiens | Q13625 | 24366813 | |
|
Intra
|
PPP1CC | P36873 | TP53BP2 | Homo sapiens | Q13625 | 28330616 | |
|
Intra
|
PPP1CC | P36873 | TP53BP2 | Homo sapiens | Q13625 | 28330616 | |
|
Intra
|
PPP1CC | P36873 | TP53BP2 | Homo sapiens | Q13625 | 21988832 | |
|
Intra
|
PPP1CC | P36873 | ESR1 | Homo sapiens | P03372 | 17274640 | |
|
Cross
|
PPP1CC | P36873 | Clock | Mus musculus | O08785 | 23555304 | |
|
Intra
|
PPP1CC | P36873 | ZNF629 | Homo sapiens | Q9UEG4 | 32296183 |
Recombinant PPP1CC Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P71228 | PPP1CC Protein, Human (His) | P36873-1 (M1-K323) | ≥ 85%, as determined by reducing SDS-PAGE. |
PPP1CC Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P81323 | PP1C gamma Antibody (YA1068) | WB | Human |
| HY-P81323A | PP1C gamma Antibody (YA1068)(PBS only) | WB | Human |
| HY-P85518 | PP1C gamma Antibody (YA5210) | WB, IHC-P, FC | Human |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Rheumatoid Arthritis |
|
|
| Rasopathy |
|
|
| Microcephaly |
|
|
| Noonan Syndrome 1 |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Mus musculus | PPP1CC | MGD | MGI:104872 |
| Rattus norvegicus | PPP1CC | RGD | RGD:3377 |
| Bos taurus | PPP1CC | VGNC | VGNC:53916 |
| Canis familiaris | PPP1CC | VGNC | VGNC:52957 |
| Felis catus | PPP1CC | VGNC | VGNC:80466 |
| Others | PPP1CC | NCBI |