LMTK2 - lemur tyrosine kinase 2 Gene

Homo sapiens

Also known as BREK; KPI2; LMR2; cprk; KPI-2; hBREK; AATYK2; PPP1R100

Gene ID: 22853 | Gene type: protein coding

About LMTK2

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:98,106,862-98,209,638 (from NCBI)

This gene has 2 transcripts (splice variants), 198 orthologues and 53 paralogues. Ubiquitous expression in brain (RPKM 11.9), colon (RPKM 7.7) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and Myosin VI. It phosporylates other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (CDK5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]

LMTK2 Products(1)

mRNA	Protein	Name
NM_014916.4	NP_055731.2	serine/threonine-protein kinase LMTK2 precursor

LMTK2 Protein Structure

Pkinase_Tyr

0
300
600
900
1200
1503 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase LMTK2

CDK5/p35-regulated kinase

Related Diseases

Diseases

Alias

Testicular Malignant Germ Cell Cancer

Malignant Germ Cell Tumor Of Testis

Cystic Fibrosis

Mucoviscidosis	CF
Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis	Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis
Cystic Fibrosis Lung Disease, Modifier Of	Cystic Fibrosis Of Pancreas
Fibrocystic Disease Of Pancreas	Cf - [Cystic Fibrosis]
Cystic Fibrosis Nos	Fibrocystic Disease
Fibrocystic Disease Of The Pancreas	Mucoviscidosis Of Pancreas
Nonproliferative Fibrocystic Disease	Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07725	LMTK2 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LMTK2	VGNC	VGNC:74309
Felis catus	LMTK2	VGNC	VGNC:63253
Mus musculus	LMTK2	MGD	MGI:3036247
Bos taurus	LMTK2	VGNC	VGNC:30941
Canis familiaris	LMTK2	VGNC	VGNC:42727
Rattus norvegicus	LMTK2	RGD	RGD:1598332

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