LMTK2 - lemur tyrosine kinase 2 Gene

Also Known as BREK; KPI2; LMR2; cprk; KPI-2; hBREK; AATYK2; PPP1R100

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 22853

About LMTK2

Cytogenetic location: 7q21.3 Genomic coordinates (GRCh38): 7:98,106,862-98,209,638 (from NCBI)

This gene has 2 transcripts (splice variants), 198 orthologues and 53 paralogues. Ubiquitous expression in brain (RPKM 11.9), colon (RPKM 7.7) and 25 other tissues.

Summary

The protein encoded by this gene belongs to the protein kinase superfamily and the protein tyrosine kinase family. It contains N-terminal transmembrane helices and a long C-terminal cytoplasmic tail with serine/threonine/tyrosine kinase activity. This protein interacts with several Other proteins, such as Inhibitor-2 (Inh2), protein phosphatase-1 (PP1C), p35, and Myosin VI. It phosporylates Other proteins, and is itself also phosporylated when interacting with cyclin-dependent kinase 5 (CDK5)/p35 complex. This protein involves in nerve growth factor (NGF)-TrkA signalling, and also plays a critical role in endosomal membrane trafficking. Mouse studies suggested an essential role of this protein in spermatogenesis. [provided by RefSeq, Oct 2009]

LMTK2 Products (1)

mRNA	Protein	Name
NM_014916.4	NP_055731.2	serine/threonine-protein kinase LMTK2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables myosin VI binding	IPI IPI: Inferred from physical interaction	18029400	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	12393858	GOA
enables protein phosphatase inhibitor activity	IDA IDA: Inferred from direct assay	12393858	GOA
enables protein serine/threonine kinase activity	IDA IDA: Inferred from direct assay	12393858	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in early endosome to late endosome transport	IMP IMP: Inferred from mutant phenotype	18429820	GOA
involved in endocytic recycling	IMP IMP: Inferred from mutant phenotype	18029400	GOA
involved in peptidyl-serine phosphorylation	IDA IDA: Inferred from direct assay	16887929	GOA
involved in peptidyl-threonine phosphorylation	IDA IDA: Inferred from direct assay	16887929	GOA
involved in protein autophosphorylation	IDA IDA: Inferred from direct assay	12393858	GOA
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	12393858	GOA
involved in receptor recycling	IMP IMP: Inferred from mutant phenotype	18029400	GOA
involved in transferrin transport	IMP IMP: Inferred from mutant phenotype	18029400	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in Golgi apparatus	IDA IDA: Inferred from direct assay	12832520	GOA
located in early endosome	IDA IDA: Inferred from direct assay	18029400	GOA
located in membrane	IDA IDA: Inferred from direct assay	12393858	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	12832520	GOA
located in recycling endosome	IDA IDA: Inferred from direct assay	18029400	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LMTK2 Protein Structure

Pkinase_Tyr

0
300
600
900
1200
1503 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase LMTK2	CDK5/p35-regulated kinase

LMTK2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	LMTK2	Q8IWU2	PPP1R2	Homo sapiens	P41236	BioID	35384245

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Testicular Malignant Germ Cell Cancer	Malignant Germ Cell Tumor Of Testis
Cystic Fibrosis	Mucoviscidosis CF Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis Cystic Fibrosis Lung Disease, Modifier Of Cystic Fibrosis Of Pancreas Fibrocystic Disease Of Pancreas Cf - [Cystic Fibrosis] Cystic Fibrosis Nos Fibrocystic Disease Fibrocystic Disease Of The Pancreas Mucoviscidosis Of Pancreas Nonproliferative Fibrocystic Disease Pancreatic Cystic Fibrosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS07725	LMTK2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20051	Lmtk2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26555	Lmtk2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	LMTK2	VGNC	VGNC:74309
Felis catus	LMTK2	VGNC	VGNC:63253
Mus musculus	LMTK2	MGD	MGI:3036247
Bos taurus	LMTK2	VGNC	VGNC:30941
Canis familiaris	LMTK2	VGNC	VGNC:42727
Rattus norvegicus	LMTK2	RGD	RGD:1598332
Others	LMTK2	NCBI