PPP1R2 - protein phosphatase 1 regulatory inhibitor subunit 2 Gene

Also Known as IPP2; IPP-2; PPP1R2A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5504

About PPP1R2

Cytogenetic location: 3q29 Genomic coordinates (GRCh38): 3:195,514,428-195,543,325 (from NCBI)

This gene has 7 transcripts (splice variants), 207 orthologues and 2 paralogues. Ubiquitous expression in bone marrow (RPKM 27.3), testis (RPKM 22.2) and 25 other tissues.

Summary

Protein phosphatase-1 (PP1) is one of the main eukaryotic serine/threonine phosphatases. The protein encoded by this gene binds to the catalytic subunit of PP1, strongly inhibiting its activity. Ten related pseudogenes have been found throughout the human genome. Several splice variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]

PPP1R2 Products (4)

mRNA	Protein	Name
NM_001291504.2	NP_001278433.1	protein phosphatase inhibitor 2 isoform 1
NM_001291505.2	NP_001278434.1	protein phosphatase inhibitor 2 isoform 3
NM_001316325.2	NP_001303254.1	protein phosphatase inhibitor 2 isoform 4
NM_006241.8	NP_006232.1	protein phosphatase inhibitor 2 isoform 2

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	References	Source
enables molecular function inhibitor activity	EXP EXP: Inferred from Experiment	18954090	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	10807923	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

PPP1R2 Protein Structure

IPP-2

0
100
205 a.a.

Protein Preferred Names	Protein Names
protein phosphatase inhibitor 2	phosphoprotein phosphatase

PPP1R2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	PPP1R2	P41236	LMTK2	Homo sapiens	Q8IWU2	Pull Down	12393858
Intra	PPP1R2	P41236	LMTK2	Homo sapiens	Q8IWU2	Protein Kinase Assay	12393858
Intra	PPP1R2	P41236	LMTK2	Homo sapiens	Q8IWU2	Y2H	12393858
Intra	PPP1R2	P41236	PPP1CC	Homo sapiens	P36873	BN-PAGE	10807923
Intra	PPP1R2	P41236	PPP1CC	Homo sapiens	P36873	Anti Tag CoIP	12761178
Intra	PPP1R2	P41236	PPP1CA	Homo sapiens	P62136	Y2H	22321011
Intra	PPP1R2	P41236	TINF2	Homo sapiens	Q9BSI4	Pull Down	21044950

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cataract 11, Multiple Types	Cataract, Posterior Polar, 4 Ctpp4 Cpp4 Cataract 11 Multiple Types CTRCT11 Cataract 11, Syndromic, Autosomal Recessive Cataract 11 With Microphthalmia And Neurodevelopmental Abnormalities Posterior Polar Cataract 4 Posterior Polar Cataract, 4 Cataract Posterior Polar 4 Syndromic Cataract 11 Cataract, Type 11, Multiple Types
Pulmonary Talcosis	Pneumoconiosis Due To Talc Talc Pneumoconiosis Talcosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10995	PPP1R2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	PPP1R2	RGD	RGD:621099
Mus musculus	PPP1R2	MGD	MGI:1914099
Others	PPP1R2	NCBI