AATK - apoptosis associated tyrosine kinase Gene

Homo sapiens

Also known as LMR1; AATYK; LMTK1; p35BP; AATYK1; PPP1R77

Gene ID: 9625 | Gene type: protein coding

About AATK

Cytogenetic location: 17q25.3 Genomic coordinates (GRCh38): 17:81,117,295-81,166,221 (from NCBI)

This gene has 11 transcripts (splice variants), 258 orthologues and 1 paralogue. Biased expression in brain (RPKM 12.1), duodenum (RPKM 7.0) and 11 other tissues.

Summary

The protein encoded by this gene contains a tyrosine kinase domain at the N-terminus and a proline-rich domain at the C-terminus. This gene is induced during Apoptosis, and expression of this gene may be a necessary pre-requisite for the induction of growth arrest and/or Apoptosis of myeloid precursor cells. This gene has been shown to produce neuronal differentiation in a neuroblastoma cell line. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

AATK Products(2)

mRNA	Protein	Name
NM_001080395.3	NP_001073864.2	serine/threonine-protein kinase LMTK1 isoform 1
NM_004920.3	NP_004911.2	serine/threonine-protein kinase LMTK1 isoform 2

AATK Protein Structure

Pkinase_Tyr

0
300
600
900
1200
1374 a.a.

Protein Preferred Names

Protein Names

serine/threonine-protein kinase LMTK1

CDK5-binding protein

Related Diseases

Diseases

Alias

Neuroblastoma

Nb	Neuroblastoma, Susceptibility To
Neuroblastomas	Central Neuroblastoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00035	AATK Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	AATK	MGD	MGI:1197518
Felis catus	AATK	VGNC	VGNC:59459
Bos taurus	AATK	VGNC	VGNC:25453
Rattus norvegicus	AATK	RGD	RGD:1590980
Macaca mulatta	AATK	VGNC	VGNC:69488