MICAL3 - microtubule associated monooxygenase, calponin and LIM domain containing 3 Gene

Also Known as MICAL-3

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 57553

About MICAL3

Cytogenetic location: 22q11.21 Genomic coordinates (GRCh38): 22:17,787,649-18,024,561 (from NCBI)

This gene has 20 transcripts (splice variants), 210 orthologues and 36 paralogues. Ubiquitous expression in testis (RPKM 5.1), brain (RPKM 4.5) and 25 other tissues.

Summary

Enables actin binding activity. Involved in actin filament depolymerization. Located in several cellular components, including Flemming body; intercellular bridge; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

MICAL3 Products (3)

mRNA Protein Name
NM_001122731.2 NP_001116203.1 [F-actin]-monooxygenase MICAL3 isoform 3
NM_001136004.3 NP_001129476.1 [F-actin]-monooxygenase MICAL3 isoform 2
NM_015241.3 NP_056056.2 [F-actin]-monooxygenase MICAL3 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables actin binding IDA
IDA: Inferred from direct assay
24440334 GOA
enables molecular adaptor activity EXP
EXP: Inferred from Experiment
27528609 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
27528609 GOA
Biological Process GO Annotation Evidence References Source
involved in actin filament depolymerization IDA
IDA: Inferred from direct assay
24440334 GOA
involved in cytoskeleton organization IDA
IDA: Inferred from direct assay
24440334 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleus IDA
IDA: Inferred from direct assay
24440334 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MICAL3 Protein Structure

FAD_binding_3

FAD_binding_3: FAD binding domain (87 - 124)

CH

CH: Calponin homology (CH) domain (523 - 623)

LIM

LIM: LIM domain (764 - 820)

DUF3585

DUF3585: Protein of unknown function (DUF3585) (1849 - 1989)

  • 0
  • 400
  • 800
  • 1200
  • 1600
  • 2002 a.a.
Protein Preferred Names Protein Names

[F-actin]-monooxygenase MICAL3

  • [F-actin]-methionine sulfoxide oxidase MICAL3

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Phase
HY-19893 Antroquinonol Activator 98.48% Phase 2
HY-10081 GS-6201 Antagonist 98.47% Phase 1

Pre-clinical Phase

Bioactive Molecules (15)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-13818 Stattic 99.96% Unkown
HY-14393 Emodin Inhibitor 99.25% Yes
HY-W012974 3-Aminoisobutyric acid 98.0% Unkown
HY-12363 U-69593 Agonist 99.73% Unkown
HY-14393R Emodin (Standard) Inhibitor 98.84% Unkown
HY-135555 5-Carboxamidotryptamine Agonist 98.74% Unkown
HY-100839 (RS)-(Tetrazol-5-yl)glycine Agonist 96.53% Unkown
HY-132246 WWL123 analogue-1 Inhibitor 98.04% Unkown
HY-14393S Emodin-d4 Inhibitor / Unkown
HY-122303 4-hydroxy DiPT hydrochloride Agonist 99.9% Unkown
HY-CE01152 3-Oxotetradecanoyl-CoA / Unkown
HY-RS08427 MICAL3 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-165098 3-Aminoisobutyric acid sodium salt 99.59% Unkown
HY-N0976 1,11b-Dihydro-11b-hydroxymedicarpin Activator / Unkown
HY-W197533 3-Hydroxymethyl-β-carboline / Unkown
Inhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P992108 Efadirelaxin alfa Activator / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus MICAL3 MGD MGI:2442733
Macaca mulatta MICAL3 VGNC VGNC:107800
Rattus norvegicus MICAL3 RGD RGD:1359504
Canis familiaris MICAL3 VGNC VGNC:43219
Bos taurus MICAL3 VGNC VGNC:31459
Others MICAL3 NCBI