WWL123 analogue-1

Cat. No.: HY-132246 Purity: 98.04%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

WWL123 analogue-1 is an analogue of WWL123. WWL123 is a potent and selective ABHD6 inhibitor with an IC₅₀ of 430 nM. WWL123 crosses the blood-brain-barrier and inhibits ABHD6 in brain parenchyma. ABHD6 blockade by WWL123 exerts an antiepileptic effect in Pentylenetetrazole (PTZ)-induced epileptiform seizures and spontaneous seizures in R6/2 mice.

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WWL123 analogue-1 Chemical Structure

CAS No. : 1338575-41-9

Size	Price	Stock	Quantity
Solid + Solvent
10 mM * 1 mL in DMSO ready for reconstitution	USD 181	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 181	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 165	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 280	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 588	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 940	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1505	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

WWL123 analogue-1 is an analogue of WWL123. WWL123 is a potent and selective ABHD6 inhibitor with an IC₅₀ of 430 nM^[1]^[2]. WWL123 crosses the blood-brain-barrier and inhibits ABHD6 in brain parenchyma. ABHD6 blockade by WWL123 exerts an antiepileptic effect in Pentylenetetrazole (PTZ)-induced epileptiform seizures and spontaneous seizures in R6/2 mice^[3].

Molecular Weight

436.50

Formula

C₂₈H₂₄N₂O₃

CAS No.

1338575-41-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C(C2=CC=CC(OC(N(CC3=CC=CC(C4=CC=CC=C4)=C3)C)=O)=C2)C=C1)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 50 mg/mL (114.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.2910 mL	11.4548 mL	22.9095 mL
5 mM	0.4582 mL	2.2910 mL	4.5819 mL
10 mM	0.2291 mL	1.1455 mL	2.2910 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.04%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (244 KB) HNMR (133 KB) RP-HPLC (169 KB)

Handling Instructions (2659 KB)

References

[1]. Daniel A Bachovchin, et al. Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):20941-6. [Content Brief]

[2]. Peng Zhong, et al. Genetic deletion of monoacylglycerol lipase alters endocannabinoid-mediated retrograde synaptic depression in the cerebellum. J Physiol. 2011 Oct 15;589(Pt 20):4847-55. [Content Brief]

[3]. Alipi V Naydenov, et al. ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice. Neuron. 2014 Jul 16;83(2):361-371. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.2910 mL	11.4548 mL	22.9095 mL	57.2738 mL
	5 mM	0.4582 mL	2.2910 mL	4.5819 mL	11.4548 mL
	10 mM	0.2291 mL	1.1455 mL	2.2910 mL	5.7274 mL
	15 mM	0.1527 mL	0.7637 mL	1.5273 mL	3.8183 mL
	20 mM	0.1145 mL	0.5727 mL	1.1455 mL	2.8637 mL
	25 mM	0.0916 mL	0.4582 mL	0.9164 mL	2.2910 mL
	30 mM	0.0764 mL	0.3818 mL	0.7637 mL	1.9091 mL
	40 mM	0.0573 mL	0.2864 mL	0.5727 mL	1.4318 mL
	50 mM	0.0458 mL	0.2291 mL	0.4582 mL	1.1455 mL
	60 mM	0.0382 mL	0.1909 mL	0.3818 mL	0.9546 mL
	80 mM	0.0286 mL	0.1432 mL	0.2864 mL	0.7159 mL
	100 mM	0.0229 mL	0.1145 mL	0.2291 mL	0.5727 mL