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SUMO3 - small ubiquitin like modifier 3 Gene

Also Known as SMT3A; Smt3B; SMT3H1; SUMO-3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6612

About SUMO3

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:44,805,617-44,818,062 (from NCBI)

This gene has 6 transcripts (splice variants), 221 orthologues and 3 paralogues. Ubiquitous expression in brain (RPKM 42.6), bone marrow (RPKM 40.3) and 25 other tissues.

Summary

This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to Other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, Mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014]

SUMO3 Products (2)

mRNA	Protein	Name
NM_001286416.2	NP_001273345.1	small ubiquitin-related modifier 3 isoform 2
NM_006936.3	NP_008867.2	small ubiquitin-related modifier 3 isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17000644	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in negative regulation of DNA binding	IDA IDA: Inferred from direct assay	16626738	GOA
involved in protein sumoylation	IDA IDA: Inferred from direct assay	11889051	GOA
involved in regulation of protein localization to nucleus	IDA IDA: Inferred from direct assay	19050011	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in PML body	IDA IDA: Inferred from direct assay	19050011	GOA
located in nucleus	IDA IDA: Inferred from direct assay	21965678	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SUMO3 Protein Structure

Rad60-SLD

0
103 a.a.

Protein Preferred Names	Protein Names
small ubiquitin-related modifier 3	SMT3 suppressor of mif two 3 homolog 1

SUMO3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SUMO3	P55854	CARM1	Homo sapiens	Q86X55	Anti Tag CoIP	33961781
Intra	SUMO3	P55854	USPL1	Homo sapiens	Q5W0Q7	Enzymatic Study	22878415
Intra	SUMO3	P55854	USPL1	Homo sapiens	Q5W0Q7	Pull Down	22878415
Intra	SUMO3	P55854	USPL1	Homo sapiens	Q5W0Q7	Y2H Fragment Pooling	35914814
Intra	SUMO3	P55854	ZBTB33	Homo sapiens	Q86T24	Y2H Prey Pooling	32296183
Intra	SUMO3	P55854	ZBTB33	Homo sapiens	Q86T24	Validated Y2H	32296183
Intra	SUMO3	P55854	ZBTB33	Homo sapiens	Q86T24	Y2H Array	32296183
Intra	SUMO3	P55854	ATXN2	Homo sapiens	Q99700-5	Y2H Pooling	32814053
Intra	SUMO3	P55854	ATXN2	Homo sapiens	Q99700-5	Validated Y2H	32814053
Intra	SUMO3	P55854	ATXN2	Homo sapiens	Q99700-5	Y2H Array	32814053
Intra	SUMO3	P55854	SART1	Homo sapiens	O43290	Affinity Chrom	17000644
Intra	SUMO3	P55854	SENP2	Homo sapiens	Q9HC62	Anti Tag CoIP	33961781
Intra	SUMO3	P55854	SENP2	Homo sapiens	Q9HC62	Y2H Array	25416956
Intra	SUMO3	P55854	SENP2	Homo sapiens	Q9HC62	Y2H Prey Pooling	25416956
Intra	SUMO3	P55854	ZNF496	Homo sapiens	Q96IT1	Y2H Prey Pooling	32296183
Intra	SUMO3	P55854	ZNF496	Homo sapiens	Q96IT1	Validated Y2H	32296183
Intra	SUMO3	P55854	ZNF496	Homo sapiens	Q96IT1	Y2H Array	32296183
Intra	SUMO3	P55854	ZCCHC12	Homo sapiens	Q6PEW1	Y2H Fragment Pooling	35914814
Intra	SUMO3	P55854	ZCCHC12	Homo sapiens	Q6PEW1	Y2H Prey Pooling	32296183
Intra	SUMO3	P55854	ZCCHC12	Homo sapiens	Q6PEW1	Validated Y2H	32296183
Intra	SUMO3	P55854	ZCCHC12	Homo sapiens	Q6PEW1	Y2H Array	32296183
Intra	SUMO3	P55854	SP100	Homo sapiens	P23497	Affinity Chrom	17000644
Intra	SUMO3	P55854	ZBTB39	Homo sapiens	O15060	Y2H Prey Pooling	32296183
Intra	SUMO3	P55854	ZBTB39	Homo sapiens	O15060	Y2H Array	32296183
Cross	SUMO3	P55854	RPS27A	Bos taurus	P62990	Pull Down	21857666
Cross	SUMO3	P55854	RPS27A	Bos taurus	P62990	Comigration in SDS	21857666

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SUMO3 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71346	SUMO3 Protein, Human (HEK293, His)	P55854 (S2-G92)	≥ 95%, as determined by reducing SDS-PAGE.

SUMO3 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81309A	SUMO2/3 Antibody (YA1049)	WB, IHC-P, ICC/IF	Human, Mouse, Rat

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14026	SUMO2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS14027	SUMO3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21773	Sumo3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28290	Sumo3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SUMO3	MGD	MGI:1336201
Rattus norvegicus	SUMO3	RGD	RGD:1561022
Bos taurus	SUMO3	VGNC	VGNC:56237