VRK1 - VRK serine/threonine kinase 1 Gene

Also Known as PCH1; PCH1A

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7443

About VRK1

Cytogenetic location: 14q32.2 Genomic coordinates (GRCh38): 14:96,797,382-96,881,609 (from NCBI)

This gene has 63 transcripts (splice variants), 290 orthologues, 12 paralogues and is associated with 4 phenotypes. Broad expression in bone marrow (RPKM 15.9), testis (RPKM 12.9) and 23 other tissues.

Summary

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-Jun. [provided by RefSeq, Jul 2008]

VRK1 Products (3)

mRNA	Protein	Name
NM_001411051.1	NP_001397980.1	serine/threonine-protein kinase VRK1 isoform 2
NM_001411053.1	NP_001397982.1	serine/threonine-protein kinase VRK1 isoform 3
NM_003384.3	NP_003375.1	serine/threonine-protein kinase VRK1 isoform 1

VRK1 Protein Structure

Pkinase

0
100
200
300
396 a.a.

Protein Preferred Names	Protein Names
serine/threonine-protein kinase VRK1	vaccinia related kinase 1

VRK1 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	VRK1	Q99986	ATF2	Homo sapiens	P15336	Protein Kinase Assay	15105425
Intra	VRK1	Q99986	RAN	Homo sapiens	P62826	Anti Bait CoIP	18617507
Intra	VRK1	Q99986	RAN	Homo sapiens	P62826	Pull Down	18617507
Intra	VRK1	Q99986	TP53	Homo sapiens	P04637	Pull Down	24492002
Intra	VRK1	Q99986	TP53	Homo sapiens	P04637	Anti Bait CoIP	24492002
Intra	VRK1	Q99986	TP53	Homo sapiens	P04637	Protein Kinase Assay	29340707
Intra	VRK1	Q99986	TP53	Homo sapiens	P04637	Anti Tag CoIP	24492002
Intra	VRK1	Q99986	RNF8	Homo sapiens	O76064	Anti Tag CoIP	26869104
Intra	VRK1	Q99986	TP53BP1	Homo sapiens	Q12888	Phosphotransferase	22621922
Intra	VRK1	Q99986	TP53BP1	Homo sapiens	Q12888	Anti Bait CoIP	22621922
Intra	VRK1	Q99986	KAT5	Homo sapiens	Q92993	Anti Bait CoIP	33076429
Intra	VRK1	Q99986	KAT5	Homo sapiens	Q92993	Pull Down	33076429
Intra	VRK1	Q99986	KAT5	Homo sapiens	Q92993	Anti Tag CoIP	33076429
Intra	VRK1	Q99986	KAT5	Homo sapiens	Q92993	Protein Kinase Assay	33076429
Intra	VRK1	Q99986	H2AX	Homo sapiens	P16104	Anti Bait CoIP	25923214
Intra	VRK1	Q99986	SOX2	Homo sapiens	P48431	Pull Down	27334688
Intra	VRK1	Q99986	SOX2	Homo sapiens	P48431	Confocal	27334688
Intra	VRK1	Q99986	AURKB	Homo sapiens	Q96GD4	Pull Down	29340707
Intra	VRK1	Q99986	AURKB	Homo sapiens	Q96GD4	Confocal	29340707
Intra	VRK1	Q99986	AURKB	Homo sapiens	Q96GD4	Protein Kinase Assay	29340707
Intra	VRK1	Q99986	AURKB	Homo sapiens	Q96GD4	Anti Bait CoIP	29340707
Intra	VRK1	Q99986	AURKB	Homo sapiens	Q96GD4	Anti Tag CoIP	29340707
Intra	VRK1	Q99986	PLK3	Homo sapiens	Q9H4B4	Pull Down	19103756
Intra	VRK1	Q99986	PLK3	Homo sapiens	Q9H4B4	Confocal	19103756
Intra	VRK1	Q99986	PLK3	Homo sapiens	Q9H4B4	Anti Bait CoIP	19103756
Intra	VRK1	Q99986	PLK3	Homo sapiens	Q9H4B4	Anti Tag CoIP	19103756
Intra	VRK1	Q99986	COIL	Homo sapiens	P38432	Pull Down	21920476
Intra	VRK1	Q99986	COIL	Homo sapiens	P38432	Confocal	21920476
Intra	VRK1	Q99986	COIL	Homo sapiens	P38432	Anti Bait CoIP	21920476
Intra	VRK1	Q99986	COIL	Homo sapiens	P38432	Protein Kinase Assay	21920476

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant VRK1 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P77504	VRK1 Protein, Human (sf9)	Q99986 (N-G&P, M1-K396)	≥ 95%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases	Alias
Pontocerebellar Hypoplasia, Type 1a	Pontocerebellar Hypoplasia Type 1a PCH1A Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy Pontocerebellar Hypoplasia With Anterior Horn Cell Disease Pch1 Pontocerebellar Hypoplasia 1a Hypoplasia, Pontocerebellar, Type 1a Pontocerebellar Hypoplasia Type 1
Microcephaly-Complex Motor And Sensory Axonal Neuropathy Syndrome
Pontocerebellar Hypoplasia, Type 1e	Pontocerebellar Hypoplasia Type 1 PCH1E Norman Disease Pch1 Pontocerebellar Hypoplasia With Anterior Horn Cell Disease Pontocerebellar Hypoplasia With Infantile Spinal Muscular Atrophy Pontocerebellar Hypoplasia Type 1e Pontocerebellar Hypoplasia 1e Doid:0112322 Doid:0112330
Spinal Muscular Atrophy	Sma 5q Sma Proximal Sma Sma-Associated Sma Spinal Amyotrophies Spinal Amyotrophy Spinal Muscle Degeneration Spinal Muscle Wasting Muscular Atrophy Spinal Atrophy, Muscular, Spinal Hereditary Motor Neuronopathy Progressive Muscular Atrophy Sma - [Spinal Muscular Atrophy]
Vaccinia
Pontocerebellar Hypoplasia, Type 1b	Pontocerebellar Hypoplasia Type 1b PCH1B Pontocerebellar Hypoplasia 1b Hypoplasia, Pontocerebellar, Type 1b
Pontocerebellar Hypoplasia	Pch Congenital Pontocerebellar Hypoplasia Opch Hypoplasia, Pontocerebellar Pontoneocerebellar Hypoplasia Nonsyndromic Pontocerebellar Hypoplasia
Charcot-Marie-Tooth Hereditary Neuropathy	Distal Spinal Muscular Atrophy Distal Hereditary Motor Neuropathy Dhmn Hereditary Motor/Sensory Neuropathy Hmsn Dsma Distal Hereditary Motor Neuropathies Spinal Muscular Atrophy Distal Neuropathy, Motor, Distal, Hereditary Charcot-Marie-Tooth Disease
Juvenile Amyotrophic Lateral Sclerosis	Jals Juvenile Charcot Disease Juvenile Lou Gehrig Disease Amyotrophic Lateral Sclerosis, Juvenile
Non-Syndromic Pontocerebellar Hypoplasia	Pontoneocerebellar Hypoplasia Pch Pontoneocerebellar Atrophy
Muscular Atrophy	Muscle Wasting Amyotrophia Wasting - Muscle Skeletal Muscle Atrophy
Hereditary Breast Ovarian Cancer Syndrome	Hereditary Breast And Ovarian Cancer Syndrome Brca1- And Brca2-Associated Hereditary Breast And Ovarian Cancer Breast And/Or Ovarian Cancer Breast And Ovarian Cancer Syndrome Hboc Syndrome Hereditary Breast And Ovarian Cancer Brca1- Brca2-Associated Hboc
Congenital Contractures	Congenital Contracture
Motor Neuron Disease	Anterior Horn Cell Disease Motor Neuron Diseases Mnd - [Motor Neurone Disease] Lou Gehrig Disease Creeping Palsy Creeping Paralysis Bulbar Motor Neuron Disease Bulbar Syndrome Anterior Horn Cell Disorder Hereditary Motor Neuron Disease
Epidermolysis Bullosa, Junctional 1b, Severe	Epidermolysis Bullosa, Junctional, Herlitz Type Epidermolysis Bullosa Letalis JEB1B Epidermolysis Bullosa Junctionalis, Herlitz Type Jeb-Herlitz Type Herlitz-Pearson-Type Epidermolysis Bullosa Junctional Epidermolysis Bullosa Herlitz Type Jeb-H Junctional Epidermolysis Bullosa Generalisata Gravis Junctional Epidermolysis Bullosa, Herlitz-Pearson Type Epidermolysis Bullosa, Junctional, Generalized Severe Epidermolysis Bullosa, Junctional, Herlitz-Pearson Type Herlitz Type Epidermolysis Bullosa Junctionalis Severe Generalized Junctional Epidermolysis Bullosa Junctional Epidermolysis Bullosa, Herlitz Type Severe Generalized Jeb Epidermolysis Letalis Junctional Epidermolysis Bullosa Gravis Junctional Epidermolysis Bullosa Herlitz-Pearson Type Herlitz Disease
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Joubert Syndrome 1	Joubert Syndrome Jbts Cerebellooculorenal Syndrome 1 JBTS1 Joubert-Boltshauser Syndrome Cerebelloparenchymal Disorder Iv Cpd4 Cors1 Joubert Syndrome And Related Disorders Jsrd Familial Aplasia Of The Vermis Joubert Syndrome Related Disorders Js Cerebellar Vermis Agenesis Cerebelloparenchymal Disorder 4 Agenesis Of Cerebellar Vermis Cerebello-Oculo-Renal Syndrome Cors Joubert-Bolthauser Syndrome Cpd Iv Classic Joubert Syndrome Joubert Syndrome Type A Pure Joubert Syndrome Cerebello-Oculo-Renal Syndrome 1 Joubert Syndrome-1 Joubert Syndrome, Type 1 Joubert'S Syndrome
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-126542	VRK-IN-1	Inhibitor	99.47%	Unkown
HY-158975	VRK1/CK1-IN-1	Inhibitor	98.69%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	VRK1	VGNC	VGNC:80780
Canis familiaris	VRK1	VGNC	VGNC:48302
Bos taurus	VRK1	VGNC	VGNC:36834
Mus musculus	VRK1	MGD	MGI:1261847
Macaca mulatta	VRK1	VGNC	VGNC:81603
Rattus norvegicus	VRK1	RGD	RGD:1306069
Others	VRK1	NCBI