Eml4 - echinoderm microtubule associated protein like 4 Gene

Also Known as 4930443C24Rik

Species: Mus musculus

Gene Type: protein coding
Gene ID: 78798

Summary

Predicted to enable alpha-tubulin binding activity; beta-tubulin binding activity; and microtubule binding activity. Acts upstream of or within negative regulation of microtubule depolymerization. Located in mitotic spindle. Is expressed in cortical plate; limb; musculature; and retina. Orthologous to human EML4 (EMAP like 4). [provided by Alliance of Genome Resources, Apr 2022]

Eml4 Products (7)

mRNA Protein Name
NM_001114361.1 NP_001107833.1 echinoderm microtubule-associated protein-like 4 isoform 1
NM_001114362.1 NP_001107834.1 echinoderm microtubule-associated protein-like 4 isoform 2
NM_001286567.1 NP_001273496.1 echinoderm microtubule-associated protein-like 4 isoform 4
NM_001357886.1 NP_001344815.1 echinoderm microtubule-associated protein-like 4 isoform 5
NM_001379373.1 NP_001366302.1 echinoderm microtubule-associated protein-like 4 isoform 6
NM_001379374.1 NP_001366303.1 echinoderm microtubule-associated protein-like 4 isoform 7
NM_199466.3 NP_955760.3 echinoderm microtubule-associated protein-like 4 isoform 3

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
acts upstream of or within negative regulation of microtubule depolymerization IMP
IMP: Inferred from mutant phenotype
17196341 MGI
Cellular Component GO Annotation Evidence References Source
located in microtubule cytoskeleton IDA
IDA: Inferred from direct assay
17196341 MGI
located in mitotic spindle IDA
IDA: Inferred from direct assay
17196341 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

echinoderm microtubule-associated protein-like 4

  • EMAP-4

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-12215 Lorlatinib 99.99% Yes
HY-12215R Lorlatinib (Standard) 99.92% Unkown

Pre-clinical Phase

Bioactive Molecules (30)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-153386 CPD-1224 Inhibitor 99.83% Unkown
HY-112140 JH-VIII-157-02 Inhibitor 98.98% Unkown
HY-164397 XMU-MP-5 99.00% Unkown
HY-111752 EML4-ALK kinase inhibitor 1 Inhibitor 98.02% Unkown
HY-170928 DA-0157 Inhibitor 99.59% Unkown
HY-135509 Lorlatinib acetate / Unkown
HY-105369 KF-20444 / Unkown
HY-131244 ALK-IN-9 Inhibitor / Unkown
HY-143557 Trk-IN-7 Inhibitor / Unkown
HY-155227 ALK/EGFR-IN-1 / Unkown
HY-155227A ALK/EGFR-IN-2 Inhibitor / Unkown
HY-155227B ALK/EGFR-IN-3 Inhibitor / Unkown
HY-161749 PROTAC ALK degrader-1 Degrader / Unkown
HY-161750 PROTAC ALK degrader-2 Degrader / Unkown
HY-161910 SH-E4A-66 Inhibitor / Unkown
HY-165284 CM-118 Inhibitor / Unkown
HY-170592 dALK-3 Degrader / Unkown
HY-174315 WZH-17-002 / Unkown
HY-174368 PROTAC EML4-ALK Degrader-1 / Unkown
HY-175527 ALK degrader 2 / Unkown
HY-175849 ALK degrader 1 / Unkown
HY-180956 PROTAC ALK degrader-5 / Unkown
HY-180964 Lys-PEG3-BA Degrader / Unkown
HY-180965 Pro-PEG3-BA / Unkown
HY-180966 Gly-PEG3-BA Degrader / Unkown
HY-180970 TD-004 Degrader / Unkown
HY-180972 PROTAC EML4-ALK Degrader-2 Inhibitor / Unkown
HY-E70713 EML4 ALK Recombinant Human Active Protein Kinase / Unkown
HY-E70714 EML4 ALK F1174L Recombinant Human Active Protein Kinase / Unkown
HY-RS04356 EML4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Eml4 NCBI NCBI:27436