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Cat. No.: HY-187801

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SH-CER-6

SH-CER-6 is a double-warhead C²-COUPL derived from Ceritinib (HY-187801) that targets the EML4-ALK fusion protein complex and induces its degradation. SH-CER-6 simultaneously binds to structures near the ALK inhibitor-binding region and forms a covalent conjugate with a protein cysteine, thereby promoting ubiquitination and proteasome-dependent degradation of the EML4-ALK complex, which in turn inhibits the ALK signaling pathway. SH-CER-6 is useful for research related to ALK-positive non-small cell lung cancer.

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화학식: C₄₄H₅₁ClN₈O₇S
분자량:871.44

보관:

Please store the product under the recommended conditions in the Certificate of Analysis.

SH-CER-6 Chemical Structure

Amount: USD 0.00

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Cellular Effect
- In Vitro
Chemical Information
Protocol (2)
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H3122	DC₅₀	20 nM	Proteasome-mediated, ubiquitin-dependent degradation of EML4-ALK fusion protein in human NCI-H3122 non-small cell lung cancer cells. Proteasome-mediated, ubiquitin-dependent degradation of EML4-ALK fusion protein in human NCI-H3122 non-small cell lung cancer cells.	42506886

In Vitro

SH-CER-6 (20 nM) induces proteasome-mediated, ubiquitin-dependent degradation of EML4-ALK in NCI-H3122 non-small cell lung cancer cells with a DC₅₀ of 20 nM^[1].
SH-CER-6 mediates cysteine-dependent degradation of EML4-ALK in multiple ALK-positive non-small cell lung cancer cell lines^[1].
SH-CER-6 shows ALK-dependent toxicity comparable to parental ceritinib in a panel of non-small cell lung cancer cell lines, with dual warheads improving potency relative to a non-covalent analog^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Chemical Information

분자량 871.44
화학식 C₄₄H₅₁ClN₈O₇S
SMILES

ClC(C(NC1=CC=CC=C1S(C(C)C)(=O)=O)=N2)=CN=C2NC3=CC(C)=C(C=C3OC(C)C)C4CCN(C(CCNC(C5=CC(NC(C=C)=O)=CC(NC(C=C)=O)=C5)=O)=O)CC4
선적

Room temperature in continental US; may vary elsewhere.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocol

All Molecular Biology

Immunoprecipitation
Immunoprecipitation (IP) is an experimental method that uses the principle of antibody specific binding to purify and enrich target proteins.
Co-Immunoprecipitation
Co-immunoprecipitation technology can verify protein interaction based on the specific immune reaction between antibodies and antigens.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Yang D, et al. Systematic Targeting of Protein Complexes with Molecular COUPLrs. Cancer discovery. 2026 Jul 27.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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