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Cat. No.: HY-187801

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SH-CER-6

SH-CER-6 is a double-warhead C²-COUPL derived from Ceritinib (HY-187801) that targets the EML4-ALK fusion protein complex and induces its degradation. SH-CER-6 simultaneously binds to structures near the ALK inhibitor-binding region and forms a covalent conjugate with a protein cysteine, thereby promoting ubiquitination and proteasome-dependent degradation of the EML4-ALK complex, which in turn inhibits the ALK signaling pathway. SH-CER-6 is useful for research related to ALK-positive non-small cell lung cancer.

For research use only. We do not sell to patients.

Formula: C₄₄H₅₁ClN₈O₇S
Molecular Weight:871.44

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

SH-CER-6 Chemical Structure

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
Chemical Information
Purity & Documentation
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Biological Activity

Description

Cellular Effect

Cell Line	Type	Value	Description	References
NCI-H3122	DC₅₀	20 nM	Proteasome-mediated, ubiquitin-dependent degradation of EML4-ALK fusion protein in human NCI-H3122 non-small cell lung cancer cells. Proteasome-mediated, ubiquitin-dependent degradation of EML4-ALK fusion protein in human NCI-H3122 non-small cell lung cancer cells.	42506886

In Vitro

SH-CER-6 (20 nM) induces proteasome-mediated, ubiquitin-dependent degradation of EML4-ALK in NCI-H3122 non-small cell lung cancer cells with a DC₅₀ of 20 nM^[1].
SH-CER-6 mediates cysteine-dependent degradation of EML4-ALK in multiple ALK-positive non-small cell lung cancer cell lines^[1].
SH-CER-6 shows ALK-dependent toxicity comparable to parental ceritinib in a panel of non-small cell lung cancer cell lines, with dual warheads improving potency relative to a non-covalent analog^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Chemical Information

Molecular Weight 871.44
Formula C₄₄H₅₁ClN₈O₇S
SMILES

ClC(C(NC1=CC=CC=C1S(C(C)C)(=O)=O)=N2)=CN=C2NC3=CC(C)=C(C=C3OC(C)C)C4CCN(C(CCNC(C5=CC(NC(C=C)=O)=CC(NC(C=C)=O)=C5)=O)=O)CC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Yang D, et al. Systematic Targeting of Protein Complexes with Molecular COUPLrs. Cancer discovery. 2026 Jul 27.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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