PROTAC ALK degrader-2
PROTAC ALK degrader-2 (B1-PEG) is an ALK degrader based on PROTACs, with the DC50 of 45 nM in H3122 EML4-ALK DC50 (GSH+). PROTAC ALK degrader-2, through PEGylation, is engineered to self-organize into micelles in water and releases its active form in response to the tumor-specific high GSH environment.
For research use only. We do not sell to patients.
- Formula: C55H70ClN11O12S3.(C2H4O)n
- Molecular Weight:3100 (Approximately)
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
Chemical Information
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Molecular Weight 3100 (Approximately)
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Formula C55H70ClN11O12S3.(C2H4O)n
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SMILES
CC(C)S(C1=C(NC2=C(Cl)C=NC(NC3=C(OC(C)C)C=C(C4CCN(CC(N(CC(NCCNC5=CC=CC(C(N6C7CCC(NC7=O)=O)=O)=C5C6=O)=O)CCSSCCNC(COCCOCCO)=O)=O)CC4)C(C)=C3)=N2)C=CC=C1)(=O)=O.[n]
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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