EML4 - EMAP like 4 Gene

Also Known as C2orf2; ELP120; EMAP-4; EMAPL4; ROPP120

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 27436

About EML4

Cytogenetic location: 2p21 Genomic coordinates (GRCh38): 2:42,169,353-42,332,548 (from NCBI)

This gene has 8 transcripts (splice variants), 212 orthologues, 9 paralogues and is associated with 96 phenotypes. Ubiquitous expression in appendix (RPKM 24.1), duodenum (RPKM 22.4) and 25 other tissues.

Summary

This gene is a member of the echinoderm microtubule associated protein-like family. The encoded WD-repeat protein may be involved in microtubule formation. Abnormal fusion of parts of this gene with portions of the anaplastic lymphoma receptor tyrosine kinase gene, which generates EML4-ALK fusion transcripts, is one of the primary mutations associated with non-small cell lung Cancer. Alternative splicing of this gene results in two transcript variants. [provided by RefSeq, Jan 2015]

EML4 Products (3)

mRNA	Protein	Name
NM_001145076.3	NP_001138548.2	echinoderm microtubule-associated protein-like 4 isoform b
NM_001410776.1	NP_001397705.1	echinoderm microtubule-associated protein-like 4 isoform c
NM_019063.5	NP_061936.3	echinoderm microtubule-associated protein-like 4 isoform a

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables alpha-tubulin binding	IDA IDA: Inferred from direct assay	31409757	GOA
enables beta-tubulin binding	IDA IDA: Inferred from direct assay	31409757	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25789526	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in attachment of spindle microtubules to kinetochore	IMP IMP: Inferred from mutant phenotype	25789526	GOA
involved in mitotic metaphase chromosome alignment	IMP IMP: Inferred from mutant phenotype	25789526	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	16890222	GOA
located in microtubule	IDA IDA: Inferred from direct assay	16890222	GOA
located in microtubule organizing center	IDA IDA: Inferred from direct assay	16890222	GOA
located in midbody	IDA IDA: Inferred from direct assay	25789526	GOA
located in mitotic spindle	IDA IDA: Inferred from direct assay	16890222	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

EML4 Protein Structure

HELP

WD40

0
200
400
600
800
981 a.a.

Protein Preferred Names	Protein Names
echinoderm microtubule-associated protein-like 4	echinoderm microtubule associated protein like 4

Related Diseases

Diseases	Alias
Lymphoma	Lymphoid Cancer Lymphomas Lymphoid Cancers Lymphoid Neoplasm Lymphoma Nos Nhl - [Non-Hodgkin Lymphoma] Non-Hodgkin Lymphoma Non-Hodgkin Lymphoma, Nos Non-Hodgkin Malignant Lymphoma Nos
Lung Cancer	Lung Carcinoma Non-Small Cell Lung Carcinoma Lung Cancer, Susceptibility To Lung Cancer, Protection Against Adenocarcinoma Of Lung, Somatic Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer Lung Neoplasm Carcinoma Of Lung Lung Non-Small Cell Carcinoma Non-Small Cell Lung Cancer Nsclc Lung Neoplasms Malignant Neoplasm Of Lung Alveolar Cell Carcinoma Nonsmall Cell Lung Cancer, Somatic Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In Nonsmall Cell Lung Cancer, Susceptibility To Lung Cancer, Somatic Lung Cancer, Resistance To Cancer Of Lung Cancer Of Bronchus Cancer Of The Lung Lung Malignancies Lung Malignant Tumors Malignant Lung Tumor Malignant Tumor Of Lung Pulmonary Cancer Pulmonary Carcinoma Pulmonary Neoplasms Respiratory Carcinoma LNCR Adenocarcinoma Of Lung Neoplasm Of Lung Cancer Lung Carcinoma Non-Small Cell Lung Carcinoma, Non-Small-Cell Lung Lung Cancers Lung Carcinomas Cancer, Lung Cancer, Lung, Non-Small Cell Primary Malignant Neoplasm Of Lung Bronchioloalveolar Adenocarcinoma
Signet Ring Lung Adenocarcinoma
Nephroma	Benign Nephroma
Inflammatory Myofibroblastic Tumor	Inflammatory Fibrosarcoma
Anaplastic Large Cell Lymphoma	Alcl Cd30 Positive Anaplastic Large Cell Lymphoma Ki-1 Positive Anaplastic Large Cell Lymphoma Primary Systemic Alcl Sacl Ki-1+ Anaplastic Large Cell Lymphoma
Lung Combined Large Cell Neuroendocrine Carcinoma	Combined Large Cell Neuroendocrine Carcinoma Of Lung Pulmonary Combined Large Cell Neuroendocrine Carcinoma Combined Large Cell Lung Neuroendocrine Carcinoma
Lung Non-Squamous Non-Small Cell Carcinoma	Non- Squamous Nsclc
Mesenchymal Cell Neoplasm	Benign Miscellaneous Mesenchymal Tumor Mesenchymal Tumor Mesenchymal Tumors
Congenital Fibrosarcoma	Infantile Fibrosarcoma
Childhood Fibrosarcoma	Pediatric Fibrosarcoma
Epithelioid Inflammatory Myofibroblastic Sarcoma
Pulmonary Adenocarcinoma In Situ	Bronchioalveolar Carcinoma
Occipital Lobe Neoplasm	Neoplasm Of Occipital Lobe Malignant Neoplasm Of Occipital Lobe Tumor Of Occipital Lobe
Lung Sarcomatoid Carcinoma	Sarcomatoid Carcinoma Of The Lung Pulmonary Sarcomatoid Carcinoma
Congenital Mesoblastic Nephroma	Mesoblastic Nephroma Nephroma, Mesoblastic
Lung Carcinoma In Situ
Pleomorphic Carcinoma
Thyroid Gland Hurthle Cell Carcinoma	Oncocytic Carcinoma Of The Thyroid Thyroid Cancer, Hurthle Cell
Lung Large Cell Carcinoma	Large Cell Carcinoma Of Lung Large Cell Lung Carcinoma Large Cell Lung Cancer
Large Cell Carcinoma	Carcinoma, Large Cell Carcinoma Large Cell
Fibrolamellar Carcinoma	Fibrolamellar Hepatocellular Carcinoma Fhcc Fibrolamellar Hepatocarcinoma Hepatocellular Carcinoma, Fibrolamellar Oncocytic Hepatocellular Tumor Eosinophilic Glassy Cell Hepatoma Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis Fl-Hcc Fibrolamellar Oncocytic Hepatoma Hepatocellular Carcinoma With Increased Stromal Fibrosis Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma
Gastrointestinal Stromal Tumor	GIST Gastrointestinal Stromal Tumors Gastrointestinal Stromal Sarcoma Gastrointestinal Stromal Tumor, Familial Gant Gastrointestinal Stromal Tumour Stromal Tumor Of Gastrointestinal Tract Stromal Tumour Of Gastrointestinal Tract Gastrointestinal Stromal Neoplasm Paraganglioma And Gastric Stromal Sarcoma Plexosarcoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-12215	Lorlatinib		99.99%	Yes
HY-12215R	Lorlatinib (Standard)		99.92%	Unkown

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-180970	TD-004	Degrader	/	Phase 3

Pre-clinical Phase

Bioactive Molecules (31)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-153386	CPD-1224	Inhibitor	99.83%	Unkown
HY-112140	JH-VIII-157-02	Inhibitor	98.98%	Unkown
HY-164397	XMU-MP-5		99.00%	Unkown
HY-111752	EML4-ALK kinase inhibitor 1	Inhibitor	98.02%	Unkown
HY-169481	AP-1		97.8%	Unkown
HY-170928	DA-0157	Inhibitor	99.59%	Unkown
HY-135509	Lorlatinib acetate		/	Unkown
HY-105369	KF-20444		/	Unkown
HY-131244	ALK-IN-9	Inhibitor	/	Unkown
HY-143557	Trk-IN-7	Inhibitor	/	Unkown
HY-146022	SIAIS117	Degrader	/	Unkown
HY-155227	ALK/EGFR-IN-1		/	Unkown
HY-155227A	ALK/EGFR-IN-2	Inhibitor	/	Unkown
HY-155227B	ALK/EGFR-IN-3	Inhibitor	/	Unkown
HY-161749	PROTAC ALK degrader-1	Degrader	/	Unkown
HY-161750	PROTAC ALK degrader-2	Degrader	/	Unkown
HY-161910	SH-E4A-66	Inhibitor	/	Unkown
HY-165284	CM-118	Inhibitor	/	Unkown
HY-170592	dALK-3	Degrader	/	Unkown
HY-174315	WZH-17-002	Degrader	/	Unkown
HY-174368	PROTAC EML4-ALK Degrader-1		/	Unkown
HY-175527	ALK degrader 2		/	Unkown
HY-175849	ALK degrader 1		/	Unkown
HY-180956	PROTAC ALK degrader-5		/	Unkown
HY-180964	Lys-PEG3-BA	Degrader	/	Unkown
HY-180965	Pro-PEG3-BA		/	Unkown
HY-180966	Gly-PEG3-BA	Degrader	/	Unkown
HY-180972	PROTAC EML4-ALK Degrader-2	Inhibitor	/	Unkown
HY-E70713	EML4 ALK Recombinant Human Active Protein Kinase		/	Unkown
HY-E70714	EML4 ALK F1174L Recombinant Human Active Protein Kinase		/	Unkown
HY-RS04356	EML4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	EML4	MGD	MGI:1926048
Felis catus	EML4	VGNC	VGNC:61851
Macaca mulatta	EML4	VGNC	VGNC:72037
Bos taurus	EML4	VGNC	VGNC:28478
Rattus norvegicus	EML4	RGD	RGD:1304690
Canis familiaris	EML4	VGNC	VGNC:40349
Others	EML4	NCBI