REG4 - regenerating family member 4 Gene

Homo sapiens

Also known as GISP; RELP; REG-IV

Gene ID: 83998 | Gene type: protein coding

About REG4

Cytogenetic location: 1p12 Genomic coordinates (GRCh38): 1:119,794,017-119,811,460 (from NCBI)

This gene has 4 transcripts (splice variants), 111 orthologues and 5 paralogues. Biased expression in small intestine (RPKM 174.4), colon (RPKM 137.8) and 2 other tissues.

Summary

Enables heparin binding activity and mannan binding activity. Predicted to act upstream of or within response to bacterium. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

REG4 Products(3)

mRNA	Protein	Name
NM_001159352.2	NP_001152824.1	regenerating islet-derived protein 4 isoform 1 precursor
NM_001159353.2	NP_001152825.1	regenerating islet-derived protein 4 isoform 2 precursor
NM_032044.4	NP_114433.1	regenerating islet-derived protein 4 isoform 1 precursor

REG4 Protein Structure

Lectin_C

0
100
158 a.a.

Protein Preferred Names

Protein Names

regenerating islet-derived protein 4

REG-4

Recombinant REG4 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P71257	REG-4 Protein, Human (HEK293, His)	Q9BYZ8 (D23-P158)	≥95%
HY-P74597	REG-4 Protein, Human (HEK293, Fc)	Q9BYZ8 (D23-P158)	≥95%

Related Diseases

Diseases

Alias

Ulcerative Colitis

Colitis Gravis	Left Sided Ulcerative Colitis
Left-Sided Ulcerative Colitis	Idiopathic Proctocolitis
Inflammatory Bowel Disease, Ulcerative Colitis Type	Uc
Colitis Ulcerative	Colitis, Ulcerative
Chronic Left-Sided Ulcerative Colitis	Uc - [Ulcerative Colitis]
Chronic Ulcerative Enteritis	Mucosal Proctocolitis
Ulcerative Mucosal Proctocolitis	Left Hemicolitis

Pseudomyxoma Peritonei

Adenomucinosis	Gelatinous Ascites
Pmp	Mucinous Ascites
Syndrome Of Pseudomyxoma Peritonei

Bladder Urachal Carcinoma

Urachal Cancer

Urachal Carcinoma

Urachus Cancer

Malignant Tumor Of Urachus

Cystadenoma

Cystoma

Craniopharyngioma

Colitis

Crohn'S Disease

Crohn Disease	Pediatric Crohn'S Disease
Regional Enteritis	Crohn'S Disease Of Large Bowel
Granulomatous Colitis	Enteritis, Granulomatous
Enteritis	Crohn'S Disease Of Colon
Colitis, Granulomatous	Crohn'S Enteritis
Enteritis, Regional	Ileitis
Adenoviral Enteritis	Acute Gastroenteropathy Due To Norwalk Agent
Viral Gastroenteritis Due To Norwalk Agent	Winter Vomiting
Epidemic Winter Vomiting Disease	Small Round Structured Virus Enteritis
Epidemic Vomiting Syndrome	Epidemic Vomiting
Epidemic Nausea	Epidemic Viral Gastroenteritis Due To Norwalk Virus
Noroviral Enteritis	Crohn Disease Nos
Crohns	Cd - [Crohn'S Disease]
Regional Enteritis Of Bowel	Crohn'S Regional Enteritis
Cobble-Stone Appearance Of Intestine	Intestinal Ulcer And Erosion Due To Crohn Disease
Granulomatous Enteritis

Appendix Cancer

Appendiceal Neoplasms	Cancer Of The Appendix
Malignant Neoplasm Of Appendix Vermiformis	Malignant Tumor Of Appendix
Malignant Tumor Of The Appendix	Malignant Neoplasm Of Appendix
Carcinoma Of The Appendix

Appendix Disease

Disorder Of Appendix

Gastric Cancer

Stomach Cancer	Gastric Carcinoma
Stomach Carcinoma	Gastric Cancer, Somatic
Gastric Neoplasm	Carcinoma Of Stomach
Stomach Neoplasms	Malignant Neoplasm Of Stomach
Gastric Cancer Risk After H. Pylori Infection	Cancer Of The Stomach
Adult Stomach Cancer	Adult Stomach Carcinoma
GASC	Gastric Cancer Intestinal
Gastric Cancers	Gastric Carcinomas
Cancer, Gastric	Stomach Neoplasm
Malignant Neoplasm Of Body Of Stomach	Malignant Tumor Of Lesser Curve Of Stomach
Gastrocarcinoma Of Unspecified Site	Leather Bottle Stomach
Carcinoma Of Fundus Of Stomach	Cancer Of Fundus Of Stomach
Primary Malignant Neoplasm Of Body Of Stomach	Cancer Of Body Of Stomach
Primary Malignant Neoplasm Of Pyloric Antrum	Pyloric Antrum Cancer
Malignant Tumour Of Stomach

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11822	REG4 Human Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	REG4	RGD	RGD:1303341
Mus musculus	REG4	MGD	MGI:1914959
Bos taurus	REG4	VGNC	VGNC:55669
Others	REG4	NCBI