REG4 - regenerating family member 4 Gene

Also Known as GISP; RELP; REG-IV

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 83998

About REG4

Cytogenetic location: 1p12 Genomic coordinates (GRCh38): 1:119,794,017-119,811,460 (from NCBI)

This gene has 4 transcripts (splice variants), 111 orthologues and 5 paralogues. Biased expression in small intestine (RPKM 174.4), colon (RPKM 137.8) and 2 other tissues.

Summary

Enables heparin binding activity and mannan binding activity. Predicted to act upstream of or within response to bacterium. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]

REG4 Products (3)

mRNA Protein Name
NM_001159352.2 NP_001152824.1 regenerating islet-derived protein 4 isoform 1 precursor
NM_001159353.2 NP_001152825.1 regenerating islet-derived protein 4 isoform 2 precursor
NM_032044.4 NP_114433.1 regenerating islet-derived protein 4 isoform 1 precursor

Gene Ontology

  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
NOT enables calcium ion binding IDA
IDA: Inferred from direct assay
20692269 GOA
enables heparin binding IDA
IDA: Inferred from direct assay
20692269 GOA
enables mannan binding IDA
IDA: Inferred from direct assay
20692269 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
12819006 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REG4 Protein Structure

Lectin_C

Lectin_C: Lectin C-type domain (49 - 155)

  • 0
  • 100
  • 158 a.a.
Protein Preferred Names Protein Names

regenerating islet-derived protein 4

  • REG-4

Recombinant REG4 Proteins

Cat. No. Product Name Accession Purity
HY-P71257 REG-4 Protein, Human (HEK293, His) Q9BYZ8-1 (D23-P158) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P74597 REG-4 Protein, Human (HEK293, Fc) Q9BYZ8-1 (D23-P158) ≥ 90%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Ulcerative Colitis

  • Colitis Gravis

  • Left Sided Ulcerative Colitis

  • Left-Sided Ulcerative Colitis

  • Idiopathic Proctocolitis

  • Inflammatory Bowel Disease, Ulcerative Colitis Type

  • Uc

  • Colitis Ulcerative

  • Colitis, Ulcerative

  • Chronic Left-Sided Ulcerative Colitis

  • Uc - [Ulcerative Colitis]

  • Chronic Ulcerative Enteritis

  • Mucosal Proctocolitis

  • Ulcerative Mucosal Proctocolitis

  • Left Hemicolitis
Pseudomyxoma Peritonei

  • Adenomucinosis

  • Gelatinous Ascites

  • Pmp

  • Mucinous Ascites

  • Syndrome Of Pseudomyxoma Peritonei
Bladder Urachal Carcinoma

  • Urachal Cancer

  • Urachal Carcinoma
Urachus Cancer

  • Malignant Tumor Of Urachus
Cystadenoma

  • Cystoma

  • Craniopharyngioma
Colitis
Crohn'S Disease

  • Crohn Disease

  • Pediatric Crohn'S Disease

  • Regional Enteritis

  • Crohn'S Disease Of Large Bowel

  • Granulomatous Colitis

  • Enteritis, Granulomatous

  • Enteritis

  • Crohn'S Disease Of Colon

  • Colitis, Granulomatous

  • Crohn'S Enteritis

  • Enteritis, Regional

  • Ileitis

  • Adenoviral Enteritis

  • Acute Gastroenteropathy Due To Norwalk Agent

  • Viral Gastroenteritis Due To Norwalk Agent

  • Winter Vomiting

  • Epidemic Winter Vomiting Disease

  • Small Round Structured Virus Enteritis

  • Epidemic Vomiting Syndrome

  • Epidemic Vomiting

  • Epidemic Nausea

  • Epidemic Viral Gastroenteritis Due To Norwalk Virus

  • Noroviral Enteritis

  • Crohn Disease Nos

  • Crohns

  • Cd - [Crohn'S Disease]

  • Regional Enteritis Of Bowel

  • Crohn'S Regional Enteritis

  • Cobble-Stone Appearance Of Intestine

  • Intestinal Ulcer And Erosion Due To Crohn Disease

  • Granulomatous Enteritis
Appendix Cancer

  • Appendiceal Neoplasms

  • Cancer Of The Appendix

  • Malignant Neoplasm Of Appendix Vermiformis

  • Malignant Tumor Of Appendix

  • Malignant Tumor Of The Appendix

  • Malignant Neoplasm Of Appendix

  • Carcinoma Of The Appendix
Appendix Disease

  • Disorder Of Appendix
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Inflammatory Bowel Disease

  • Inflammatory Bowel Diseases

  • Bowel Disease, Inflammatory
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS11822 REG4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18368 Reg4 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24847 Reg4 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus REG4 RGD RGD:1303341
Mus musculus REG4 MGD MGI:1914959
Bos taurus REG4 VGNC VGNC:55669
Others REG4 NCBI