ECRG4 - ECRG4 augurin precursor Gene

Also Known as C2orf40

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 84417

About ECRG4

Cytogenetic location: 2q12.2 Genomic coordinates (GRCh38): 2:106,063,241-106,078,155 (from NCBI)

This gene has 6 transcripts (splice variants) and 216 orthologues. Broad expression in fat (RPKM 29.6), thyroid (RPKM 20.4) and 17 other tissues.

Summary

Enables neuropeptide hormone activity. Involved in neuropeptide signaling pathway; positive regulation of hormone secretion; and vasopressin secretion. Located in apical plasma membrane; dense core granule; and extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

ECRG4 Products (1)

mRNA Protein Name
NM_032411.3 NP_115787.1 augurin precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables neuropeptide hormone activity IGI
IGI: Inferred from genetic interaction
20233222 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in neuropeptide signaling pathway IGI
IGI: Inferred from genetic interaction
20233222 GOA
involved in positive regulation of corticosterone secretion IGI
IGI: Inferred from genetic interaction
20233222 GOA
involved in positive regulation of corticotropin secretion IGI
IGI: Inferred from genetic interaction
20233222 GOA
involved in positive regulation of corticotropin-releasing hormone secretion IGI
IGI: Inferred from genetic interaction
20233222 GOA
involved in vasopressin secretion IGI
IGI: Inferred from genetic interaction
20233222 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in apical plasma membrane IDA
IDA: Inferred from direct assay
21349154 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21349154 GOA
located in dense core granule IDA
IDA: Inferred from direct assay
17284679 GOA
located in extracellular space IDA
IDA: Inferred from direct assay
17284679 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ECRG4 Protein Structure

Augurin

Augurin: Oesophageal cancer-related gene 4 (32 - 148)

  • 0
  • 100
  • 148 a.a.
Protein Preferred Names Protein Names

augurin

  • esophageal cancer related gene 4 protein

ECRG4 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
ECRG4 Q9H1Z8 WFS1 Homo sapiens O76024
Validated Y2H
32814053
Intra
ECRG4 Q9H1Z8 WFS1 Homo sapiens O76024
Y2H Array
32814053
Intra
ECRG4 Q9H1Z8 WFS1 Homo sapiens O76024
Y2H Pooling
32814053
Intra
ECRG4 Q9H1Z8 UBQLN2 Homo sapiens Q9UHD9
Validated Y2H
32296183
Intra
ECRG4 Q9H1Z8 UBQLN2 Homo sapiens Q9UHD9
Y2H Array
32296183
Intra
ECRG4 Q9H1Z8 UBQLN2 Homo sapiens Q9UHD9
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Esophageal Cancer

  • Esophageal Carcinoma

  • Carcinoma Of Esophagus

  • Esophageal Squamous Cell Carcinoma, Somatic

  • Esophageal Carcinoma, Somatic

  • Esophagus Cancer

  • Gastric Cardia Adenocarcinoma

  • Esophageal Neoplasms

  • Esophageal Cancer, Somatic

  • Cancer Of Esophagus

  • Cancer Of Oesophagus

  • Carcinoma Of Oesophagus

  • Ca Lower Third Oesophagus

  • Ca Middle Third Oesophagus

  • Malignant Neoplasm Of Distal Third Of Esophagus

  • Malignant Neoplasm Of Lower Third Of Oesophagus

  • Malignant Neoplasm Of Middle Third Of Oesophagus

  • Malignant Neoplasm Of Proximal Third Of Esophagus

  • Malignant Neoplasm Of Upper Third Esophagus

  • Malignant Tumor Of Abdominal Esophagus

  • Malignant Tumor Of Distal Third Of Esophagus

  • Malignant Tumor Of Proximal Third Of Esophagus

  • Malignant Tumor Of The Middle Third Of The Esophagus

  • ESCR

  • Aerodigestive Tract Cancer

  • Escc

  • Esophageal Squamous Cell Carcinoma

  • Cancer, Esophageal

  • Malignant Neoplasm Of Esophagus

  • Squamous Cell Carcinoma Of Esophagus

  • Malignant Neoplasm Of Middle Third Of Esophagus
Castration-Resistant Prostate Carcinoma

  • Prostatic Neoplasms, Castration-Resistant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS04146 ECRG4 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Rattus norvegicus ECRG4 RGD RGD:1305645
Canis familiaris ECRG4 VGNC VGNC:52481
Bos taurus ECRG4 VGNC VGNC:59206
Mus musculus ECRG4 MGD MGI:1926146
Macaca mulatta ECRG4 VGNC VGNC:82138
Felis catus ECRG4 VGNC VGNC:61714
Others ECRG4 NCBI