2. GPCR/G Protein
  3. GCGR
  4. Glucagon (22-29)

Glucagon (22-29) is partial agonist of Glucagon (19–29). Glucagon specifically inhibits the Ca2+ pump in liver plasma membranes independently of adenylate cyclase activation.

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Glucagon (22-29)

Glucagon (22-29) Estructura química

No. CAS : 32204-93-6

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Glucagon (22-29) Related Antibodies

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Descripciòn

Glucagon (22-29) is partial agonist of Glucagon (19–29). Glucagon specifically inhibits the Ca2+ pump in liver plasma membranes independently of adenylate cyclase activation[1][2].

In Vitro

Glucagon (22-29) produces only a 5-15% maximal inhibition of (Ca2+-Mg2+) ATPase, with a low potency (Ki=1 μM), similar to that of native glucagon[1].
Glucagon (22-29) (10 nM) evokes an early small decrease of cell contraction when added alone and an 18% significant positive inotropic effect when added in combination with 30 nM glucagon. Glucagon (22-29) thus appears to act as a partial agonist of miniglucagon[2].
Glucagon (22-29) consists of the COOH-terminal part of miniglucagon but lacks the three Ala1g-Gln20-Asp21 residues[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glucagon (22-29) Related Antibodies
Peso molecular

1038.22

Fòrmula

C49H71N11O12S
No. CAS
Appearance

Solid

Color

White to off-white

Sequence Shortening

FVQWLMNT
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (96.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.9632 mL 4.8159 mL 9.6319 mL
5 mM 0.1926 mL 0.9632 mL 1.9264 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Working solution concentration: mg/mL
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Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.9632 mL 4.8159 mL 9.6319 mL 24.0797 mL
5 mM 0.1926 mL 0.9632 mL 1.9264 mL 4.8159 mL
10 mM 0.0963 mL 0.4816 mL 0.9632 mL 2.4080 mL
15 mM 0.0642 mL 0.3211 mL 0.6421 mL 1.6053 mL
20 mM 0.0482 mL 0.2408 mL 0.4816 mL 1.2040 mL
25 mM 0.0385 mL 0.1926 mL 0.3853 mL 0.9632 mL
30 mM 0.0321 mL 0.1605 mL 0.3211 mL 0.8027 mL
40 mM 0.0241 mL 0.1204 mL 0.2408 mL 0.6020 mL
50 mM 0.0193 mL 0.0963 mL 0.1926 mL 0.4816 mL
60 mM 0.0161 mL 0.0803 mL 0.1605 mL 0.4013 mL
80 mM 0.0120 mL 0.0602 mL 0.1204 mL 0.3010 mL
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Glucagon (22-29) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glucagon (22-29)32204-93-6GCGRGlucagon ReceptorGlucagonCa2+ATPasecell contractionminiglucagonInhibitorinhibitorinhibit

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Nombre del producto:
Glucagon (22-29)
Cat. No.:
HY-P3617
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