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Cat. No.: HY-180446

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Glucagon receptor antagonist-11

Glucagon receptor antagonist-11 (Compound 14) is a glucagon receptor antagonist with a pIC₅₀ of 6.677. Glucagon receptor antagonist-10 can be used in studies of glucose homeostasis.

For research use only. We do not sell to patients.

CAS No.: 152121-19-2
Formula: C₂₁H₁₃FN₄
Molecular Weight:340.35

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

Glucagon receptor antagonist-11 Chemical Structure

CAS No.: 152121-19-2

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

Glucagon receptor antagonist-11 (Compound 14) is a glucagon receptor antagonist with a pIC₅₀ of 6.677. Glucagon receptor antagonist-10 can be used in studies of glucose homeostasis^[1].

IC₅₀ & Target

pIC₅₀: 6.677 (Glucagon receptor)^[1]

Cellular Effect

Cell Line	Type	Value	Description	References
RBL-1	Inhibition	66 % Compound: 30	Inhibitory activity against 5-lipoxygenase enzyme from RBL-1 cells at 20 uM Inhibitory activity against 5-lipoxygenase enzyme from RBL-1 cells at 20 uM	10.1016/0960-894X(95)00189-Z

Chemical Information

CAS No. 152121-19-2
Molecular Weight 340.35
Formula C₂₁H₁₃FN₄
SMILES

N#CC1=CC=C(C2=NC(C3=CC=NC=C3)=C(C4=CC=C(F)C=C4)N2)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (268 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Shahlaei M, et al. Prediction of glucagon receptor antagonist activities of some substituted imidazoles using combined radial basis function neural network and density functional theory. Medicinal Chemistry Research, 2014, 23(6): 2744-2756.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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