2. Apoptosis Epigenetics Cell Cycle/DNA Damage Cytoskeleton
  3. Apoptosis HDAC Microtubule/Tubulin
  4. HDAC6-IN-73

HDAC6-IN-73 is a highly potent and selective HDAC6 inhibitor with an IC50 of 0.007 μM ± 0.001, ~1771-fold selectivity over HDAC1, ~131-fold selectivity over HDAC8, and antiproliferative activity in hematological cancer cell lines.HDAC6-IN-73 can be used for the research of hematological malignancies.

For research use only. We do not sell to patients.

HDAC6-IN-73

HDAC6-IN-73 Chemical Structure

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HDAC6-IN-73 Related Antibodies

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Description

HDAC6-IN-73 is a highly potent and selective HDAC6 inhibitor with an IC50 of 0.007 μM ± 0.001, ~1771-fold selectivity over HDAC1, ~131-fold selectivity over HDAC8, and antiproliferative activity in hematological cancer cell lines.HDAC6-IN-73 can be used for the research of hematological malignancies[1].

IC50 & Target

HDAC6

7 nM (IC50)

HDAC1

12.4 μM (IC50)

HDAC8

0.92 μM (IC50)

In Vitro

HDAC6-IN-73 (compound 7c) significantly inhibits the proliferation of Jurkat, Namalwa, and K-562 cells[1].
HDAC6-IN-73 exhibits micromolar cytotoxicity against hematological cancer cell lines, and shows stronger activity against malignant cells compared to some normal cells[1].
HDAC6-IN-73 (50 μM; 48 h) induces significant late and early apoptosis in Namalwa cells and causes accumulation of Namalwa cells at the sub-G1 phase; no obvious cell cycle changes are observed in Jurkat or K-562 cells[1].
HDAC6-IN-73 (50 μM; 24 h) induces significant α-tubulin acetylation in Jurkat and Namalwa cells, with minimal effects on histone H3 acetylation; no α-tubulin acetylation is detected in K-562 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HDAC6-IN-73 Related Antibodies

Cell Viability Assay[1]

Cell Line: Jurkat, Namalwa, and K-562 cells; HS-5, CCD-18Co, HaCaT cells
Concentration: IC50 assay
Incubation Time: 72 h
Result: Exhibited the strongest antiproliferative effects against Jurkat, Namalwa, and K-562 cells with IC50 of 3.7 μM, 7.7 μM, 18 μM; as well as inhibiting HS-5, CCD-18Co, HaCaT cells with 9.3 μM, 33 μM, and 10.3 μM.

Apoptosis Analysis[1]

Cell Line: Jurkat, Namalwa, and K-562 cells
Concentration: 50 μM
Incubation Time: 48 h
Result: Induced significant late and early apoptosis in Namalwa cells, with apoptosis rates at 50 μM exceeding those of reference compounds.
Promoted accumulation of cells in the sub-G1 phase in Namalwa cells; showed no significant cell cycle changes in Jurkat or K-562 cells.

Western Blot Analysis[1]

Cell Line: Jurkat, Namalwa, and K-562 cells
Concentration: 50 μM
Incubation Time: 24 h
Result: Induced marked acetylation of α-tubulin with minimal effect on histone H3 acetylation in Jurkat and Namalwa cells; showed no detectable α-tubulin acetylation in K-562 cells.
Molecular Weight

412.48

Formula

C23H28N2O5
SMILES

CCCCCCC(N(CC1=CC=C(C(NO)=O)C=C1)CC2=CC(OCO3)=C3C=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HDAC6-IN-73 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HDAC6-IN-73ApoptosisHDACMicrotubule/TubulinHistone deacetylasesHDAC6hematological malignanciesnormal cell typesHDAC8HDAC1hematological cancer cell linesInhibitorinhibitorinhibit

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