HDAC6-IN-83
HDAC6-IN-83 is a selective histone deacetylase 6 (HDAC6) inhibitor with an IC50 value of 11.49 nM. HDAC6-IN-83 selectively increases the acetylation level of α-tubulin without affecting histone H3. HDAC6-IN-83 induces cell apoptosis, induces cell cycle arrest, inhibits cancer cell proliferation, suppresses cancer cell invasion and inhibits angiogenesis. HDAC6-IN-83 can be used in non-small cell lung cancer research.
For research use only. We do not sell to patients.
- CAS No.: 3053098-60-2
- Formula: C25H23N3O3
- Molecular Weight:413.47
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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HDAC6 11.49 nM (IC50) |
HDAC6-IN-83 (Compound P21) (0.27-5.92 μM; 48 h) exhibits broad-spectrum antiproliferative activity against various cancer cell lines, with IC50 values ranging from 0.27 μM to 5.92 μM, and shows favorable safety profiles in normal HEK293 cells[1].
HDAC6-IN-83 (0.01-0.2 μM; 12 h) selectively increases the acetylation level of α-tubulin in RPMI 8226 cells after 12 h of treatment, without affecting the acetylation of histone H3[1].
HDAC6-IN-83 (0.1-10 μM; 24-48 h) dose-dependently inhibits the invasive ability of A549 cells, with significant inhibition observed at concentrations as low as 1 μM[1].
HDAC6-IN-83 (0.01-1.25 μM; 24 h) dose-dependently induces apoptosis in Jurkat cells[1].
HDAC6-IN-83 (0.05-0.25 μM; 24 h) induces G2/M cell cycle arrest in Jurkat cells following treatment with 0.25 μM for 24 h[1].
HDAC6-IN-83 (0.1-10 μM; 6 h) dose-dependently inhibits angiogenesis in human umbilical vein endothelial cells (HUVEC)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:Jurkat cells
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Concentration:0.01, 0.05, 0.25, 1.25 μM
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Incubation Time:24 h
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Result:Induced apoptosis in Jurkat cells in a dose-dependent manner.
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Cell Line:Jurkat cells
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Concentration:0.05, 0.25 μM
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Incubation Time:24 h
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Result:Induced cycle arrest in Jurkat cells.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:BALB/c-nu (male, 4-6 weeks old)[1]
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Dosage:25 mg/kg; 50 mg/kg
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Administration:i.p.; once every two days; 14 days
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Result:Significantly inhibited tumor volume compared to the control group.
Halted tumor growth at 50 mg/kg.
Showed no significant morphological abnormalities in kidney, heart, liver, or lung tissues from the 50 mg/kg treatment group compared to the control group.
Chemical Information
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CAS No. 3053098-60-2
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Molecular Weight 413.47
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Formula C25H23N3O3
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SMILES
COC(C=C1)=CC=C1CN(CC2=CC=C(C(NO)=O)C=C2)C3=C(N=CC=C4)C4=CC=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC6-IN-83 Related Classifications
HY-184304 Related Classifications
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