CDK8 - cyclin dependent kinase 8 Gene

Also Known as K35; IDDHBA

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 1024

About CDK8

Cytogenetic location: 13q12.13 Genomic coordinates (GRCh38): 13:26,254,129-26,405,238 (from NCBI)

This gene has 11 transcripts (splice variants), 217 orthologues, 26 paralogues and is associated with 2 phenotypes. Ubiquitous expression in testis (RPKM 6.1), duodenum (RPKM 3.9) and 25 other tissues.

Summary

This gene encodes a member of the cyclin-dependent protein kinase (CDK) family. CDK family members are known to be important regulators of cell cycle progression. This kinase and its regulatory subunit, cyclin C, are components of the Mediator transcriptional regulatory complex, involved in both transcriptional activation and repression by phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II. This kinase regulates transcription by targeting the cyclin-dependent kinase 7 subunits of the general transcription initiation factor IIH, thus providing a link between the Mediator complex and the basal transcription machinery. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2016]

CDK8 Products (5)

mRNA	Protein	Name
NM_001318368.2	NP_001305297.1	cyclin-dependent kinase 8 isoform 2
NM_001346501.2	NP_001333430.1	cyclin-dependent kinase 8 isoform 3
XM_047430033.1	XP_047285989.1	cyclin-dependent kinase 8 isoform X1
XM_011534865.3	XP_011533167.1	cyclin-dependent kinase 8 isoform X2
NM_001260.3	NP_001251.1	cyclin-dependent kinase 8 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7568034	GOA
enables protein kinase activity	IMP IMP: Inferred from mutant phenotype	30905399	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15009212	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of CKM complex	IPI IPI: Inferred from physical interaction	19047373	GOA
part of cyclin-dependent protein kinase holoenzyme complex	IDA IDA: Inferred from direct assay	21806996	GOA
part of mediator complex	IDA IDA: Inferred from direct assay	14638676	GOA
part of mediator complex	IMP IMP: Inferred from mutant phenotype	30905399	GOA
located in nucleolus	IDA IDA: Inferred from direct assay	22869755	GOA
located in nucleus	IDA IDA: Inferred from direct assay	16109376	GOA
part of protein-containing complex	IDA IDA: Inferred from direct assay	22869755	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CDK8 Protein Structure

Pkinase

0
100
200
300
400
464 a.a.

Protein Preferred Names	Protein Names
cyclin-dependent kinase 8	CDK8 protein kinase cell division protein kinase 8 mediator complex subunit CDK8 mediator of RNA polymerase II transcription subunit CDK8 protein kinase K35

CDK8 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CDK8	P49336	CCNC	Homo sapiens	P24863	Anti Tag CoIP	19047373

Cross: Cross-species interaction Intra: Intraspecies interaction

CDK8 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81578	CDK8 Antibody (YA1323)	WB, IHC-P, IHC-F, IF-Tissue	Human, Mouse, Rat

Related Diseases

Diseases	Alias
Med23	Intellectual Disability, Autosomal Recessive 18 Autosomal Recessive Nonsyndromic Mental Retardation-18
Thoracic Benign Neoplasm	Benign Neoplasm Of Thorax
Ebstein Anomaly	Ebstein'S Anomaly Ebstein'S Anomaly Of Common Atrioventricular Valve Ebstein'S Anomaly Of Right Atrioventricular Valve Ebstein'S Anomaly Of Tricuspid Valve Ebstein'S Malformation Ebstein Malformation Of The Tricuspid Valve Ebstein Anomaly Of The Tricuspid Valve Ebstein Disease Accessory Tricuspid Valve Tissue Congenital Ebstein Deformity Of Tricuspid Valve Ebstein Syndrome Ebstein Cardiopathy Ebstein Anomaly Of Tricuspid Valve
Opitz-Kaveggia Syndrome	Fg Syndrome Fgs1 Fgs Keller Syndrome OKS Fg Syndrome 1 Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of Corpus Callosum Fg Syndrome Type 1 Mental Retardation, Large Head, Imperforate Anus, Congenital Hypotonia, And Partial Agenesis Of The Corpus Callosum
Ohdo Syndrome	Young Simpson Syndrome Ohdo Blepharophimosis Syndrome Blepharophimosis Syndrome Ohdo Type Blepharophimosis Intellectual Disability Syndromes Bmrs Blepharophimosis-Intellectual Disability Syndrome Mental Retardation, Congenital Heart Disease, Blepharophimosis, Blepharoptosis, And Hypoplastic Teeth Blepharophimosis Mental Retardation Syndromes Sbbys Syndrome Say Barber Biesecker Young-Simpson Syndrome Blepharophimosis-Intellectual Disability Syndrome, Ohdo Type Bmrs, Ohdo Type Blepharophimosis Syndrome, Ohdo Type Ohdo-Madokoro-Sonoda Syndrome Blepharophimosis - Intellectual Disability Syndrome, Ohdo Type Blepharophimosis - Intellectual Disability Syndrome
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Congenital Anomaly Of Heart Heart Defect Heart Malformation Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon
Uterine Benign Neoplasm
Developmental And Epileptic Encephalopathy 87	DEE87 Epileptic Encephalopathy, Early Infantile, 87 Eiee87 Developmental And Epileptic Encephalopathy, 87 Early Infantile Epileptic Encephalopathy 87
Learning Disability	Learning Disabilities Learning Disorders Academic Skill Disorder Learning Disorder
Intellectual Developmental Disorder With Hypotonia And Behavioral Abnormalities	IDDHBA
Heart, Malformation Of
Hydrocephalus, Congenital, 1	Hydrocephaly Ventriculomegaly Hydrocephalus, Nonsyndromic, Autosomal Recessive 1 HYC1 Congenital Non-Communicating Hydrocephalus Hydrocephalus, Nonsyndromic, Autosomal Recessive 1, Formerly Congenital Obstructive Hydrocephalus Hydrocephalus, Non-Syndromic, Autosomal Recessive 1 Hydrocephalus
Diaphragmatic Hernia, Congenital	Congenital Diaphragmatic Hernia Diaphragmatic Hernia Hernia, Congenital Diaphragmatic 1 Cdh Congenital Diaphragmatic Defect Hernia, Diaphragmatic Dih Hernia, Congenital Diaphragmatic Hcd Diaphragmatic Defect, Congenital Diaphragm, Unilateral Agenesis Of Hemidiaphragm, Agenesis Of Agenesis Of Hemidiaphragm Unilateral Agenesis Of Diaphragm Hernia Diaphragmatic Hernia Diaphragmatic Congenital Hiatus Hernia Oesophageal Hiatus Hernia Paraoesophageal Hernia Sliding Hiatus Hernia Congenital Diaphragm Hernia Congenital Diaphragm Defect With Hernia Gross Congenital Diaphragm Defect
Attention Deficit-Hyperactivity Disorder	Attention Deficit Hyperactivity Disorder ADHD Attention Deficit Disorder Attention Deficit-Hyperactivity Disorder, Susceptibility To Attention Deficit Disorder With Hyperactivity Hyperkinetic Disorder Hyperactivity Of Childhood Attention-Deficit/Hyperactivity Disorder Add Addh Attention Deficit Attention Deficit Disorder Of Childhood With Hyperactivity Attention Deficit Disorder With Hyperactivity Syndrome Hyperkinetic Syndrome Attention-Deficit Hyperactivity Disorder Attention-Deficit/Hyperactivity Disorder, Predominantly Inattentive Type Disturbance Of Activity And Attention Disorder Of Activity And Attention Adhd - [Attention Deficit Hyperactivity Disorder] Hyperkinetic Disorders Disorder Of Activity And Attention With Hyperkinesia Attention Deficit Syndrome With Hyperactivity
Breast Benign Neoplasm	Benign Tumour Of Breast Benign Neoplasm Of Female Breast

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Phase
HY-X0009	Tambiciclib	Inhibitor	99.68%	Phase 2
HY-137478	KB-0742	Inhibitor	99.63%	Phase 2
HY-137478A	KB-0742 dihydrochloride	Inhibitor	98.77%	Phase 2
HY-X0009A	Tambiciclib dimaleate	Inhibitor	99.53%	Phase 2
HY-101800	Senexin B	Inhibitor	99.09%	Phase 1
HY-111388B	Romaciclib hydrochloride	Inhibitor	99.98%	Phase 1

Pre-clinical Phase

Bioactive Molecules (46)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-N0400	Wogonin	Inhibitor	99.83%	Unkown
HY-120350	BI-1347	Inhibitor	99.85%	Unkown
HY-126675A	AS2863619	Inhibitor	98.02%	Unkown
HY-111388A	Romaciclib monohydrochloride	Inhibitor	99.29%	Unkown
HY-15681	Senexin A	Inhibitor	99.58%	Unkown
HY-101611	MSC2530818	Inhibitor	99.62%	Unkown
HY-19984	CCT-251921	Inhibitor	99.12%	Unkown
HY-122586	BRD6989	Inhibitor	99.54%	Unkown
HY-145121	DS96432529	Inhibitor	99.93%	Unkown
HY-12280	THZ2	Inhibitor	99.03%	Unkown
HY-156366	SNX7886	Degrader	99.71%	Unkown
HY-126675	AS2863619 free base	Inhibitor	99.87%	Unkown
HY-111518	JH-XI-10-02	Inhibitor	99.73%	Unkown
HY-149209	LL-K8-22	Degrader	99.06%	Unkown
HY-139875	JH-XVI-178	Inhibitor	98.87%	Unkown
HY-12293	LY2857785	Inhibitor	99.21%	Unkown
HY-143889	Senexin C	Inhibitor	99.19%	Unkown
HY-149974	CDK8-IN-13	Inhibitor	99.14%	Unkown
HY-168683	CDK8 ligand 1	Degrader	99.88%	Unkown
HY-151463	CDK8-IN-11	Inhibitor	98.18%	Unkown
HY-111388	SEL120-34A	Inhibitor	99.49%	Unkown
HY-111427	CDK8/19-IN-1	Inhibitor	98.08%	Unkown
HY-170813	P162-0948	Inhibitor	/	Unkown
HY-103492	CDK8-IN-1	Inhibitor	98.62%	Unkown
HY-148561	CDK8-IN-12	Inhibitor	99.74%	Unkown
HY-125001	JH-VIII-49	Inhibitor	/	Unkown
HY-15681A	Senexin A hydrochloride	Inhibitor	/	Unkown
HY-168846	CDK8/19-IN-3	Inhibitor	/	Unkown
HY-158377	CDK8/19-IN-2	Inhibitor	/	Unkown
HY-151371	CDK8-IN-10	Inhibitor	/	Unkown
HY-147716	CDK8-IN-6	Inhibitor	/	Unkown
HY-182986	LS-Q2	Inhibitor	/	Unkown
HY-137478B	KB-0742 hydrochloride	Inhibitor	/	Unkown
HY-183074	RO8323	Inhibitor	/	Unkown
HY-176281	PI3Kα-IN-26	Inhibitor	/	Unkown
HY-169541	CDK8-IN-18	Inhibitor	/	Unkown
HY-169633	CDK8-IN-17	Inhibitor	/	Unkown
HY-176282	CDK8-IN-19	Inhibitor	/	Unkown
HY-184544	CDK8 ligand 2		/	Unkown
HY-162600	CDK8-IN-15	Inhibitor	/	Unkown
HY-114178	CDK8-IN-2	Inhibitor	/	Unkown
HY-180124	CDK8-IN-20	Inhibitor	/	Unkown
HY-N0400R	Wogonin (Standard)	Inhibitor	/	Unkown
HY-147527	CDK8-IN-5	Inhibitor	/	Unkown
HY-147717	CDK8-IN-7	Inhibitor	/	Unkown
HY-171174	CDK8-IN-16	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	CDK8	MGD	MGI:1196224
Felis catus	CDK8	VGNC	VGNC:60706
Rattus norvegicus	CDK8	RGD	RGD:1560888
Macaca mulatta	CDK8	VGNC	VGNC:70984
Canis familiaris	CDK8	VGNC	VGNC:39061
Bos taurus	CDK8	VGNC	VGNC:27135
Others	CDK8	NCBI