PI3Kα-IN-26
PI3Kα-IN-26 (Compound 11e) is a PI3Kα inhibitor with an IC50 of 75.31 nM. PI3Kα-IN-26 has a broad-spectrum anticancer activity, such as leukemia, colon and breast cancer, without significant cytotoxic effect on the normal Vero cells (mean IC50s of 2.74, 3.50, 3.34 and 85.29 μM, respectively).
For research use only. We do not sell to patients.
- Formula: C24H20ClN3O3S2
- Molecular Weight:498.02
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PI3Kα 75.31 nM (IC50) |
CDK8/cyclin C 137.20 nM (IC50) |
CDK2/CycA2 3.96 μM (IC50) |
Chemical Information
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Molecular Weight 498.02
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Formula C24H20ClN3O3S2
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SMILES
O=C1/C(S/C(N1C2=CC=CC=C2)=N\CCNS(=O)(C3=CC=CC=C3)=O)=C\C4=CC=C(C=C4)Cl
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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