CDK8-IN-1
Based on 1 Customer Validation
CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.
For research use only. We do not sell to patients.
- Purity: 98.19%
- CAS No.: 1629633-48-2
- Formula: C11H8F3N3O
- Molecular Weight:255.20
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Protocol
- Purity & Documentation
- References
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Help & FAQs
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Cell Cycle/DNA Damage Compound Library
HY-L004
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Kinase Inhibitor Library
HY-L009
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Anti-Cancer Compound Library
HY-L025
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Anti-Aging Compound Library
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Anti-Breast Cancer Compound Library
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Anti-Blood Cancer Compound Library
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Cancer Stem Cells Compound Library
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Heterocyclic Compound Library
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Highly Selective Inhibitors Library
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Serine/Threonine Kinase Inhibitor Library
HY-L164
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Anti-Hematopathy Compound Library
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Anti-Ovarian Cancer Compound Library
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Bioactive Compound Library Max
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MCE Bioactive Compound Library
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Protein Kinase Compound Library
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Cell Proliferation Compound Library
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High-Throughput Bioactive Compound Library
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Posttranslational Modification Library
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High-Efficiency Gene Editing Compound Library
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Biological Activity
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CDK8 3 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
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| AGS | IC50 |
0.27 μM
Compound: 16
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Antiproliferative activity against human AGS cells after 72 hrs by MTT assay
Antiproliferative activity against human AGS cells after 72 hrs by MTT assay
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[PMID: 28802632] |
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1629633-48-2
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Appearance Solid
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Molecular Weight 255.20
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Formula C11H8F3N3O
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Color White to light brown
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SMILES
NC(C1=C(C(F)(F)F)C(C2=CC=NC=C2)=CN1)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvent & Solubility
DMSO : 100 mg/mL (391.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Protocol
Purity & Documentation
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Data Sheet (275 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.9185 mL | 19.5925 mL | 39.1850 mL | 97.9624 mL |
| 5 mM | 0.7837 mL | 3.9185 mL | 7.8370 mL | 19.5925 mL | |
| 10 mM | 0.3918 mL | 1.9592 mL | 3.9185 mL | 9.7962 mL | |
| 15 mM | 0.2612 mL | 1.3062 mL | 2.6123 mL | 6.5308 mL | |
| 20 mM | 0.1959 mL | 0.9796 mL | 1.9592 mL | 4.8981 mL | |
| 25 mM | 0.1567 mL | 0.7837 mL | 1.5674 mL | 3.9185 mL | |
| 30 mM | 0.1306 mL | 0.6531 mL | 1.3062 mL | 3.2654 mL | |
| 40 mM | 0.0980 mL | 0.4898 mL | 0.9796 mL | 2.4491 mL | |
| 50 mM | 0.0784 mL | 0.3918 mL | 0.7837 mL | 1.9592 mL | |
| 60 mM | 0.0653 mL | 0.3265 mL | 0.6531 mL | 1.6327 mL | |
| 80 mM | 0.0490 mL | 0.2449 mL | 0.4898 mL | 1.2245 mL | |
| 100 mM | 0.0392 mL | 0.1959 mL | 0.3918 mL | 0.9796 mL |
CDK8-IN-1 Related Classifications
HY-103492 Related Classifications
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