1. Cell Cycle/DNA Damage
  2. CDK

CDK8-IN-1 

Cat. No.: HY-103492
Handling Instructions

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.

For research use only. We do not sell to patients.

CDK8-IN-1 Chemical Structure

CDK8-IN-1 Chemical Structure

CAS No. : 1629633-48-2

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  • Biological Activity

  • Protocol

  • Technical Information

  • Purity & Documentation

  • References

Description

CDK8-IN-1 is a potent and selective CDK8 inhibitor with an IC50 of 3 nM.

IC50 & Target[1]

CDK8

3 nM (IC50)

In Vivo

CDK8-IN-1 displays low systemic clearance, very good exposure and oral bioavailability. The tmax is 0.25 h by PO. The mean values of Cmax are 9940 μg/L, 12740 μg/L by IV and PO respectively. The values of AUC are 9378, 25952 by IV and PO respectively[1].

References
Animal Administration
[1]

Mice[1]
CDK8-IN-1 is administrated to mice with 5 mg/kg, 25mg/mg by IV and PO respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

References
Molecular Weight

255.20

Formula

C₁₁H₈F₃N₃O

CAS No.

1629633-48-2

SMILES

NC(C1=C(C(F)(F)F)C(C2=CC=NC=C2)=CN1)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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Product Name:
CDK8-IN-1
Cat. No.:
HY-103492
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CDK8-IN-1

Cat. No.: HY-103492