CDK8/BRD4-IN-1
CDK8/BRD4-IN-1 is a dual CDK8/BRD4 inhibitor, with an IC50 of 5.44 μM against CDK8 and an IC50 of 4.03 μM against BRD4. CDK8/BRD4-IN-1 exhibits anticancer activity against colorectal cancer. CDK8/BRD4-IN-1 can be used for the research of colorectal cancer.
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- Formule: C27H36N6O
- Masse moléculaire:460.61
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
Description
IC50 & Target
[1]|
CDK8 5.44 μM (IC50) |
BRD4 4.03 μM (IC50) |
In Vitro
CDK8/BRD4-IN-1 (Compound 8d) (20 μM) inhibits purified BRD4 protein with an IC50 of 4.03 μM and 83.53% inhibition at 20 μM[1].
CDK8/BRD4-IN-1 (1-20 μM) inhibits purified CDK8 protein with an IC50 of 5.44 μM, 69.20% inhibition at 20 μM, and 26.30% inhibition at 1 μM[1].
CDK8/BRD4-IN-1 (20 μM) shows favorable selectivity toward CDK8/CycC and CDK19/CycC over other CDK family members when tested at 20 μM[1].
CDK8/BRD4-IN-1 (50 μM) inhibits the proliferation of HCT116 colorectal cancer cells with an IC50 of 12.41 μM, and inhibits SW480 cell proliferation by 98.07% at 50 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 460.61
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Formule C27H36N6O
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SMILES
CN(C(C=C1)=C(N(C(C)C)[C@@H]2C)C=C1NCCCCCCNC3=NC=NC4=C3C=CC=C4)C2=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
CDK8/BRD4-IN-1 Related Classifications
HY-184727 Related Classifications
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