P162-0948
Based on 1 Customer Validation
P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. P162-0948 reduces cell migration and protein expression of EMT-related proteins in A549 human alveolar epithelial cell lines. P162-0948 reduces phosphorylation of Smad, which suggests disruption of the TGF-β/Smad signaling pathway. P162-0948 is promising for research of pulmonary fibrosis.
For research use only. We do not sell to patients.
- CAS No.: 1358201-44-1
- Formula: C20H15FN4O2
- Molecular Weight:362.36
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Storage:
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CDK8 50.4 nM (IC50) |
Chemical Information
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CAS No. 1358201-44-1
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Appearance Solid
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Molecular Weight 362.36
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Formula C20H15FN4O2
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SMILES
FC1=CC=C(CNC(CC2=NN=C(C3=CC=C4C(C=CC=N4)=C3)O2)=O)C=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
4°C, sealed storage, away from moisture
* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
P162-0948 Related Classifications
HY-170813 Related Classifications
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