1358201-44-1
1358201-44-1
Chemical Structure
P162-0948
- CAS No.: 1358201-44-1
- Formula:C20H15FN4O2
- Molecular Weight:362.36
InChIKey: PFQAFOZMVLHHBM-UHFFFAOYSA-N
SMILES: FC1=CC=C(CNC(CC2=NN=C(C3=CC=C4C(C=CC=N4)=C3)O2)=O)C=C1
Biological Activity: P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. P162-0948 reduces cell migration and protein expression of EMT-related proteins in A549 human alveolar epithelial cell lines. P162-0948 reduces phosphorylation of Smad, which suggests disruption of the TGF-β/Smad signaling pathway. P162-0948 is promising for research of pulmonary fibrosis[1].
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P162-0948 | 99.39% | P162-0948 is a selective CDK8 inhibitor with an IC50 value of 50.4 nM. P162-0948 reduces cell migration and protein expression of EMT-related proteins in A549 human alveolar epithelial cell lines. P162-0948 reduces phosphorylation of Smad, which suggests disruption of the TGF-β/Smad signaling pathway. P162-0948 is promising for research of pulmonary fibrosis. | ||||||||||||||||||||
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