CTTN - cortactin Gene

Also Known as EMS1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2017

About CTTN

Cytogenetic location: 11q13.3 Genomic coordinates (GRCh38): 11:70,398,529-70,436,575 (from NCBI)

This gene has 15 transcripts (splice variants), 1 gene allele, 204 orthologues and 4 paralogues. Ubiquitous expression in gall bladder (RPKM 41.5), adrenal (RPKM 38.4) and 25 other tissues.

Summary

This gene is overexpressed in breast Cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the Cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During Apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Three splice variants that encode different isoforms have been identified for this gene. [provided by RefSeq, May 2010]

CTTN Products (3)

mRNA	Protein	Name
NM_001184740.2	NP_001171669.1	src substrate cortactin isoform c
NM_005231.4	NP_005222.2	src substrate cortactin isoform a
NM_138565.3	NP_612632.1	src substrate cortactin isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables profilin binding	IPI IPI: Inferred from physical interaction	24700464	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	15169891	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	17959782	GOA
involved in positive regulation of actin filament polymerization	IMP IMP: Inferred from mutant phenotype	24700464	GOA
involved in positive regulation of smooth muscle contraction	IMP IMP: Inferred from mutant phenotype	24700464	GOA

Cellular Component GO Annotation	Evidence	References	Source
colocalizes with actin filament	IDA IDA: Inferred from direct assay	12151401	GOA
located in cell cortex	IDA IDA: Inferred from direct assay	14742709	GOA
located in cortical cytoskeleton	IDA IDA: Inferred from direct assay	12151401	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	10760273	GOA
located in lamellipodium	IDA IDA: Inferred from direct assay	10760273	GOA
part of voltage-gated potassium channel complex	IDA IDA: Inferred from direct assay	12151401	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

CTTN Protein Structure

HS1_rep

SH3_9

0
100
200
300
400
500
550 a.a.

Protein Preferred Names	Protein Names
src substrate cortactin	1110020L01Rik

CTTN Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	CTTN	Q14247	EGFR	Homo sapiens	P00533	Anti Tag CoIP	24658140
Intra	CTTN	Q14247	HDAC6	Homo sapiens	Q9UBN7	IF	21847094
Intra	CTTN	Q14247	HDAC6	Homo sapiens	Q9UBN7	Pull Down	21220424
Intra	CTTN	Q14247	HDAC6	Homo sapiens	Q9UBN7	Anti Bait CoIP	21847094
Intra	CTTN	Q14247	HDAC6	Homo sapiens	Q9UBN7	Anti Tag CoIP	33961781
Intra	CTTN	Q14247	WAS	Homo sapiens	P42768	IF	15169891
Intra	CTTN	Q14247	WAS	Homo sapiens	P42768	Anti Bait CoIP	15169891
Intra	CTTN	Q14247	DNM2	Homo sapiens	P50570	NMR	16636290
Intra	CTTN	Q14247	DNM2	Homo sapiens	P50570	GMS	16636290
Intra	CTTN	Q14247	DNM2	Homo sapiens	P50570	Pull Down	16636290
Intra	CTTN	Q14247	ASAP1	Homo sapiens	Q9ULH1	Pull Down	16636290
Intra	CTTN	Q14247	ASAP1	Homo sapiens	Q9ULH1	GMS	16636290
Intra	CTTN	Q14247	ASAP1	Homo sapiens	Q9ULH1	NMR	16636290
Intra	CTTN	Q14247	ASAP1	Homo sapiens	Q9ULH1	Competition Binding	16636290
Intra	CTTN	Q14247	ASAP1	Homo sapiens	Q9ULH1	DLS	16636290
Cross	CTTN	Q14247	Srcin1	Mus musculus	Q9QWI6-2	Anti Tag CoIP	19146815
Cross	CTTN	Q14247	tir	Escherichia coli O127:H6	B7UM99	Pull Down	19419567

Cross: Cross-species interaction Intra: Intraspecies interaction

CTTN Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P80088	Cortactin Antibody (YA495)	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse
HY-P84566	Cortactin Antibody (YA4263)	WB, IHC-P, ELISA	Human, Mouse
HY-P84566A	Cortactin Antibody (YA4263)(PBS only)	WB, IHC-P, ELISA	Human, Mouse
HY-P85105	Cortactin Antibody (YA4797)	WB, IHC-P, ICC/IF, ELISA	Human, Mouse

Related Diseases

Diseases	Alias
Squamous Cell Carcinoma	Epidermoid Carcinoma Squamous Cell Cancer Carcinoma, Squamous Cell Squamous Cell Skin Cancer Malignant Squamous Cell Tumor Squamous Carcinoma Squamous Cell Epithelioma Carcinoma Squamous Cell Neoplasms, Squamous Cell Squamous Cell Carcinoma - Category Malignant Squamous Cell Neoplasm Squamous Cell Carcinoma Of Skin
Wiskott-Aldrich Syndrome	WAS Eczema-Thrombocytopenia-Immunodeficiency Syndrome Immunodeficiency 2 Aldrich Syndrome Imd2 Wiskott-Aldrich Syndrome 1 Was1 Wiskott Syndrome Wiskott Aldrich Syndrome Eczema Thrombocytopenia Immunodeficiency Syndrome Imd 2
Ethmoid Sinus Adenocarcinoma	Adenocarcinoma Of Ethmoid Sinus Adenocarcinoma Of The Ethmoid Sinus
Larynx Cancer	Laryngeal Carcinoma Laryngeal Cancer Laryngeal Neoplasm Carcinoma Of Larynx Malignant Neoplasm Of Larynx Cancer Of Larynx Laryngeal Neoplasms Cancer, Laryngeal
Aarskog-Scott Syndrome	Aarskog Syndrome Faciogenital Dysplasia Faciodigitogenital Syndrome AAS Fgdy X-Linked Aarskog Syndrome Intellectual Developmental Disorder, X-Linked, Syndromic 16 Aarskog Syndrome, X-Linked Intellectual Developmental Disorder, X-Linked Syndromic 16 Greig'S Syndrome Aarskog Scott Syndrome Aarskog Disease Scott Aarskog Syndrome Facio-Digito-Genital Dysplasia Faciogenital Dysplasia With Attention Deficit-Hyperactivity Disorder Aarskog-Scott Syndrome ) Syndrome
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Ethmoid Sinus Cancer	Malignant Neoplasm Of Ethmoidal Sinus Malignant Tumor Of Ethmoid Sinus Malignant Tumor Of Ethmoidal Sinus Neoplasm Of Ethmoidal Sinus
Frank-Ter Haar Syndrome	Ter Haar Syndrome Borrone Dermatocardioskeletal Syndrome FTHS Autosomal Recessive Melnick-Needles Syndrome Borrone Di Rocco Crovato Syndrome Megalocornea, Multiple Skeletal Anomalies, And Developmental Delay Melnick-Needles Syndrome, Autosomal Recessive, Formerly Frank Ter Haar Syndrome
Bone Squamous Cell Carcinoma
Squamous Cell Carcinoma, Head And Neck	Squamous Cell Carcinoma Of The Head And Neck HNSCC Head And Neck Squamous Cell Carcinoma Squamous Cell Carcinoma Of Lip Squamous Cell Carcinoma, Head And Neck, Somatic Carcinoma Of The Head And Neck Squamous Cell Carcinomas Of Head And Neck Scchn Squamous Cell Carcinoma Of The Hypopharynx Squamous Cell Carcinoma Of The Oropharynx Squamous Cell Carcinoma Of Salivary Glands Squamous Cell Carcinoma Of The Nasal Cavity And Paranasal Sinuses Squamous Cell Carcinoma Of The Nasal Cavity And Sinuses Squamous Cell Carcinoma Of The Oral Cavity Squamous Cell Carcinoma Of The Lip Carcinoma, Squamous Cell Of Head And Neck Lip Squamous Cell Carcinoma Carcinoma, Squamous Cell, Head And Neck Salivary Gland Squamous Cell Carcinoma Cancer Of Head And Neck Squamous Cell Carcinoma Of Oropharynx Nos
Hepatocellular Carcinoma	Liver Cancer Primary Liver Cancer HCC Hepatoma Malignant Neoplasm Of Liver Liver Neoplasms Cancer, Hepatocellular Liver Cell Carcinoma Lcc Hepatoblastoma, Somatic Hepatic Cancer Primary Malignant Neoplasm Of Liver Rare Tumor Of Liver And Intrahepatic Biliary Tract Hepatocellular Carcinoma, Somatic Hepatocellular Carcinoma, Childhood Type, Somatic Hepatocellular Cancer, Somatic Ca Liver - Primary Hepatic Neoplasm Malignant Hepato-Biliary Neoplasm Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary Malignant Neoplasm Of Liver, Primary Malignant Tumor Of Liver Neoplasm Of Liver Non-Resectable Primary Hepatic Malignant Neoplasm Resectable Malignant Neoplasm Of Liver Resectable Malignant Neoplasm Of The Liver Primary Liver Carcinoma Primary Malignant Liver Neoplasm Primary Cancer Of Liver Primary Tumor Of The Liver Rare Tumor Of Liver And Ibt Hepatocellular Cancer Neoplasm Of The Liver Carcinoma, Hepatocellular Hepatomas Liver Neoplasm Liver Carcinoma Liver And Intrahepatic Biliary Tract Carcinoma Malignant Hepatobiliary Neoplasm Adult Primary Hepatocellular Carcinoma Hepatoblastoma Carcinoma Of Liver Malignant Liver Tumour Malignant Hepatic Tumour
Lung Squamous Cell Carcinoma	Squamous Cell Carcinoma Of Lung Squamous Cell Lung Carcinoma Epidermoid Cell Carcinoma Of The Lung Squamous Cell Lung Cancer
Polycystic Kidney Disease	Polycystic Kidney Diseases Pkd Polycystic Renal Disease Kidney Disease, Polycystic Polycystic Kidney, Autosomal Dominant
Prolapse Of Urethra	Urethrocele
Colorectal Cancer	Colon Cancer Colorectal Carcinoma Colon Carcinoma Colorectal Cancer, Susceptibility To Carcinoma Of Colon CRC Colorectal Cancer With Chromosomal Instability, Somatic Colon Cancer, Somatic Colon Cancer, Susceptibility To Colonic Neoplasms Colorectal Neoplasms Colorectal Cancer, Somatic Colon Cancer, Advanced, Somatic Colonic Carcinoma Colorectal Carcinomas Colon Cancers Colorectal Cancers Cancer, Colorectal, Somatic Cancer, Colon Cancer, Colorectal, Susceptibility To Colorectal Neoplasm Colonic Neoplasm Malignant Tumor Of Colon

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03350	CTTN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22133	Cttn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28655	Cttn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	CTTN	VGNC	VGNC:61274
Mus musculus	CTTN	MGD	MGI:99695
Macaca mulatta	CTTN	VGNC	VGNC:71611
Canis familiaris	CTTN	VGNC	VGNC:39718
Bos taurus	CTTN	VGNC	VGNC:27821
Rattus norvegicus	CTTN	RGD	RGD:619839
Others	CTTN	NCBI