TAF13 - TATA-box binding protein associated factor 13 Gene

Also Known as MRT60; TAF2K; TAFII18; TAFII-18; TAF(II)18

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6884

About TAF13

Cytogenetic location: 1p13.3 Genomic coordinates (GRCh38): 1:109,064,140-109,076,003 (from NCBI)

This gene has 3 transcripts (splice variants), 230 orthologues, 1 paralogue and is associated with 3 phenotypes. Ubiquitous expression in brain (RPKM 23.1), kidney (RPKM 21.3) and 25 other tissues.

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a small subunit associated with a subset of TFIID complexes. This subunit interacts with TBP and with two Other small subunits of TFIID, TAF10 and TAF11. There is a pseudogene located on chromosome 6. [provided by RefSeq, Jul 2008]

TAF13 Products (1)

mRNA	Protein	Name
NM_005645.4	NP_005636.1	transcription initiation factor TFIID subunit 13

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables TBP-class protein binding	IPI IPI: Inferred from physical interaction	29111974	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	7729427	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in RNA polymerase II preinitiation complex assembly	IPI IPI: Inferred from physical interaction	27007846	GOA
involved in mRNA transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA
involved in positive regulation of transcription initiation by RNA polymerase II	IDA IDA: Inferred from direct assay	17884155	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in nucleus	EXP EXP: Inferred from Experiment	23332750	GOA
part of transcription factor TFIID complex	IDA IDA: Inferred from direct assay	7729427	GOA
part of transcription factor TFIID complex	IPI IPI: Inferred from physical interaction	23332750	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TAF13 Protein Structure

TFIID-18kDa

0
100
124 a.a.

Protein Preferred Names	Protein Names
transcription initiation factor TFIID subunit 13	TAF13 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 18kDa

TAF13 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	TAF13	Q15543	TAF11	Homo sapiens	Q15544	X-Ray Diffraction	9695952
Intra	TAF13	Q15543	MTUS2	Homo sapiens	Q5JR59-3	Y2H Prey Pooling	32296183
Intra	TAF13	Q15543	MTUS2	Homo sapiens	Q5JR59-3	Validated Y2H	32296183
Intra	TAF13	Q15543	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	32296183
Intra	TAF13	Q15543	MTUS2	Homo sapiens	Q5JR59-3	Y2H Array	31515488
Intra	TAF13	Q15543	MTUS2	Homo sapiens	Q5JR59	Validated Y2H	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Intellectual Developmental Disorder, Autosomal Recessive 60	Mental Retardation, Autosomal Recessive 60 MRT60 Autosomal Recessive Intellectual Developmental Disorder 60
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Schizophrenia	SCZD Schizophrenia With Or Without An Affective Disorder Schizophrenia 12 Schizophrenia, Susceptibility To Schizophrenia-1 Dementia Praecox Schizophrenia 1
Dystonia 3, Torsion, X-Linked	X-Linked Dystonia-Parkinsonism DYT3 Xdp Lubag Dystonia-Parkinsonism, X-Linked Torsion Dystonia-Parkinsonism, Filipino Type Dyt-Taf1 X-Linked Dystonia-Parkinsonism Syndrome X-Linked Torsion Dystonia-Parkinsonism Syndrome Dystonia Musculorum Deformans X-Linked Dystonia-Parkinsonism/Lubag Lubag Syndrome Dystonia-3 Torsion Dystonia-Parkinsonism Filipino Type X-Linked Torsion Dystonia 3 Dystonia, Torsion, X-Linked, Type 3
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14161	TAF13 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	TAF13	RGD	RGD:1305398
Felis catus	TAF13	VGNC	VGNC:80373
Bos taurus	TAF13	VGNC	VGNC:35568
Mus musculus	TAF13	MGD	MGI:1913500
Canis familiaris	TAF13	VGNC	VGNC:47075
Others	TAF13	NCBI