UCN - urocortin Gene

Also Known as UI; UCN1; UROC

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7349

About UCN

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:27,307,400-27,308,445 (from NCBI)

This gene has 1 transcript (splice variant), 153 orthologues and 1 paralogue. Low expression observed in reference dataset.

Summary

This gene encodes a member of the sauvagine/corticotropin-releasing factor/urotensin I family. The encoded preproprotein is proteolytically processed to generate the mature peptide, an endogenous ligand for both corticotropin-releasing factor receptor 1 and corticotropin-releasing factor receptor 2. In the brain this peptide may be responsible for the effects of stress on appetite. This peptide may also play a role in mood disorders, neurodegeneration, and skeletal system disorders. In spite of the gene family name similarity, the product of this gene has no sequence similarity to urotensin-2. [provided by RefSeq, Feb 2016]

UCN Products (1)

mRNA	Protein	Name
NM_003353.4	NP_003344.1	urocortin preproprotein

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	18234674	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of corticotropin secretion	IDA IDA: Inferred from direct assay	11329063	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

UCN Protein Structure

CRF

0
100
124 a.a.

Protein Preferred Names	Protein Names
urocortin	prepro-urocortin

Related Diseases

Diseases	Alias
Ulcerative Colitis	Colitis Gravis Left Sided Ulcerative Colitis Left-Sided Ulcerative Colitis Idiopathic Proctocolitis Inflammatory Bowel Disease, Ulcerative Colitis Type Uc Colitis Ulcerative Colitis, Ulcerative Chronic Left-Sided Ulcerative Colitis Uc - [Ulcerative Colitis] Chronic Ulcerative Enteritis Mucosal Proctocolitis Ulcerative Mucosal Proctocolitis Left Hemicolitis
Colitis
Anorexia Nervosa	Anorexia Nervosa, Susceptibility To ANON Anorexia Nervosa, Susceptibility To, 1 An Anorexia Nervosa 1 An - [Anorexia Nervosa]
Deafness, Aminoglycoside-Induced	Streptomycin Ototoxicity Deafness, Mitochondrial, Modifier Of Aminoglycoside-Induced Deafness Deafness, Streptomycin-Induced Streptomycin-Induced Deafness DFNI
Deafness, Autosomal Recessive 40	DFNB40 Autosomal Recessive Nonsyndromic Deafness 40 Autosomal Recessive Deafness 40
Deafness, Autosomal Recessive 55	DFNB55 Autosomal Recessive Nonsyndromic Deafness 55 Autosomal Recessive Deafness 55
Drug-Induced Hearing Loss	Drug Induced Hearing Loss
Dicrocoeliasis	Disease Due To Dicrocoeliidae Lancet Fluke Infection Dicroceliosis Lancet Fluke Disease Lancet Fluke Infestation
Anxiety	Anxiety Disorder Anxiety Disorders Anxiety State Anxieties Anxiety Neurosis
Heart Disease	Heart Failure Congenital Heart Disease Heart Diseases Congenital Heart Defects Congenital Heart Defect Heart Malformation Congenital Anomaly Of Heart Heart Defect Heart-Congenital Defect Congenital Heart Disorder Heart Defects Congenital Heart Defects, Congenital Heart Defects Heart Disease, Congenital Disease, Heart, Congenital Congestive Heart Failure
Isolated Growth Hormone Deficiency, Type Ib	Isolated Growth Hormone Deficiency Type Ib IGHD1B Ighd Ib Growth Hormone Deficiency, Isolated, Type Ib Congenital Ighd Type Ib Congenital Isolated Gh Deficiency Type Ib Congenital Isolated Growth Hormone Deficiency Type Ib Dwarfism Of Sindh Pituitary Dwarfism I Isolated Growth Hormone Deficiency Type 1b Ighd 1b Growth Hormone Deficiency, Isolated, 1b
Auditory System Disease	Ear Diseases Ear And Mastoid Disease
Mitochondrial Myopathy	Mitochondrial Myopathies Mitochondrial Cytopathy Myopathies In Mitochondrial Disorders
Leber Hereditary Optic Neuropathy, Modifier Of	Leber Optic Atrophy Leber Hereditary Optic Neuropathy LHON Leber'S Hereditary Optic Neuropathy Leber Optic Atrophy, Susceptibility To Leber'S Optic Atrophy LOAM Loas Leber'S Disease Leber'S Optic Neuropathy Optic Atrophy, Hereditary, Leber Lhon, Modifier Of Optic Atrophy, Leber Type Hereditary Optic Neuroretinopathy Leber Hereditary Optic Atrophy Loa Optic Atrophy Leber Type Leber Hereditary Optic Neuropathy, Modifier Leber Hereditary Optic Neuropathy Susceptibility Modifier Of Leber Hereditary Optic Neuropathy Lebers Hereditary Optic Neuropathy Leber Congenital Amaurosis
Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes	Melas Syndrome MELAS Mitochondrial Encephalomyopathy Lactic Acidosis And Stroke-Like Episodes Mitochondrial Myopathy, Lactic Acidosis, Stroke-Like Episode Mitochondrial Encephalomyopathy, Lactic Acidosis, And Stroke-Like Episodes Myopathy, Mitochondrial-Encephalopathy-Lactic Acidosis-Stroke Mitochondrial Encephalomyopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes Mitochondrial Myopathy, Encephalopathy, Lactic Acidosis And Stroke-Like Episodes Mitochondrial Encephalomyopathy With Lactic Acidosis And Stroke-Like Episodes Syndrome Myopathy, Mitochondrial, Encephalopathy, Lactic Acidosis, And Stroke-Like Episodes
Sensorineural Hearing Loss	Sensory Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss Disorder Hearing Loss, Sensorineural Central Hearing Loss High Frequency Deafness High Frequency Hearing Loss High-Frequency Hearing Loss Perceptive Deafness Perceptive Hearing Loss Perceptive Hearing Loss Or Deafness Hearing Loss Sensorineural Deafness Sensorineural Hearing Loss High-Frequency Hearing Loss, Central Hearing Loss, High-Frequency
Body Mass Index Quantitative Trait Locus 11	OBESITY Obesity, Susceptibility To Leanness, Inherited Obesity, Susceptibility To, Bmiq11 Obesity, Mild, Early-Onset Obesity, Association With Obesity, Early-Onset, Susceptibility To Obesity, Severe Obesity, Severe, And Type Ii Diabetes Obesity, Late-Onset Obesity , Susceptibility To BMIQ11 Obesity Bmiq11 Obesity, Early-Onset Simple Obesity Nos Excess Fat Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified Adiposis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-13661	7-Hydroxystaurosporine		97.8%	Phase 2

Pre-clinical Phase

Bioactive Molecules (11)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1858A	Urocortin III, mouse TFA	Activator	98.06%	Unkown
HY-105416	Calphostin C	Inhibitor	99.9%	Unkown
HY-108262	UCN-02	Inhibitor	≥98.0%	Unkown
HY-P1858	Urocortin III, mouse	Activator	98.29%	Unkown
HY-RS15407	UCN Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15408	UCN2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS15409	UCN3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17732	Ucn Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21451	Ucn3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24197	Ucn Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27969	Ucn3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	UCN	MGD	MGI:1276123
Canis familiaris	UCN	VGNC	VGNC:48108
Rattus norvegicus	UCN	RGD	RGD:3929
Macaca mulatta	UCN	VGNC	VGNC:78707
Bos taurus	UCN	VGNC	VGNC:36637
Others	UCN	NCBI