Uralodin B
Uralodin B is a naturally occurring polycyclic polyprenylated acylphloroglucinol (PPAP) and is the C (30)-epimer of Uralodin C. It is found in the aerial parts of Hypericum henryi subsp. uraloides. Uralodin B exhibits cytotoxic activity against SGC7901 and HL-60 tumor cells. It is useful for research related to PPAP natural products and tumor cytotoxicity.
For research use only. We do not sell to patients.
- CAS No.: 1253206-38-0
- Formula: C38H50O5
- Molecular Weight:586.80
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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- References
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Biological Activity
Description
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HL-60 | IC50 |
21.8 μM
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Cytotoxic activity against human HL-60 promyelocytic leukemia cells assessed by MTT assay after 48 h of continuous exposure.
Cytotoxic activity against human HL-60 promyelocytic leukemia cells assessed by MTT assay after 48 h of continuous exposure.
|
20087990 |
| SGC-7901 | IC50 |
63.7 μM
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Cytotoxic activity against human SGC7901 gastric carcinoma cells assessed by MTT assay after 48 h of continuous exposure.
Cytotoxic activity against human SGC7901 gastric carcinoma cells assessed by MTT assay after 48 h of continuous exposure.
|
20087990 |
| HepG2 | IC50 |
171.0 μM
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Cytotoxic activity against human HepG2 hepatocellular carcinoma cells assessed by MTT assay after 48 h of continuous exposure.
Cytotoxic activity against human HepG2 hepatocellular carcinoma cells assessed by MTT assay after 48 h of continuous exposure.
|
20087990 |
| K562 | IC50 |
171.0 μM
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Cytotoxic activity against human K562 chronic myelogenous leukemia cells assessed by MTT assay after 48 h of continuous exposure.
Cytotoxic activity against human K562 chronic myelogenous leukemia cells assessed by MTT assay after 48 h of continuous exposure.
|
20087990 |
In Vitro
Uralodin B (0.064-40 μM; 48 h) exerts modest cytotoxic effects against HL-60 and SGC7901 cells with IC50 values of 21.8 μM and 63.7 μM, respectively, while showing weak activity against HepG2 and K562 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HepG2 human hepatocellular carcinoma cells, SGC7901 human gastric carcinoma cells, HL-60 human promyelocytic leukemia cells, K562 human chronic myelogenous leukemia cells
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Concentration:0.064, 0.32, 1.6, 8, 40 μM
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Incubation Time:48 h
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Result:Exhibited the most potent cytotoxic activity against HL-60 cells, with an IC50 of 21.8 μM.
Showed modest cytotoxicity against SGC7901 cells, with an IC50 of 63.7 μM.
Showed minimal cytotoxic activity against HepG2 and K562 cell lines, with IC50 values of 171.0 μM for both cell lines.
Chemical Information
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CAS No. 1253206-38-0
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Molecular Weight 586.80
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Formula C38H50O5
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SMILES
O=C(C1=CC=CC=C1)[C@@]23[C@@](C)([C@H](C[C@@](C2=O)(C4=C(C[C@@H](O4)C(C)(O)C)C3=O)C/C=C(C)\C)C/C=C(C)\C)CC/C=C(C)/C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Uralodin B Related Classifications
HY-N21698 Related Classifications
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Keywords
- Uralodin B
- 1253206-38-0
- Endogenous Metabolite
- hepatocellular carcinoma
- myeloid leukemia cancer cells
- SGC7901
- bicyclo[3.3.1]nonane-2,4,9-trione core
- Hypericum henryi subsp. uraloides
- HL-60
- methylated polycyclic polyprenylated acylphloroglucinol
- HepG2
- chronic myeloid leukemia cancer cells
- gastric cancer cells
- Inhibitor
- inhibitor
- inhibit