Hypericaceae Extract

Hyperoside is a NF-κB inhibitor, found from Hypericum monogynum. Hyperoside shows anti-tumor, antifungal, anti-inflammatory, anti-viral, and anti-oxidative activities, and can induce apoptosis.

Hyperoside (Standard) is the analytical standard of Hyperoside. This product is intended for research and analytical applications. Hyperoside is a NF-κB inhibitor, found from Hypericum monogynum. Hyperoside shows anti-tumor, antifungal, anti-inflammatory, anti-viral, and anti-oxidative activities, and can induce apoptosis.

Hydrastinine hydrochloride is a major alkaloid constituent in goldenseal (Hydrastis canadensis). Hydrastinine hydrochloride can be used as a haemostatic agent.

3-Isomangostin hydrate (Compound 17) is an xanthone that can be isolated from Cratoxylum formosum ssp. pruniflorum and exhibits antibacterial activity.

Cis-Emodin bianthrone (compound 4) is a highly condensed oxygen of emodin anthrone. Cis-Emodin bianthrone stable in acetone solution in air.

Hyperwightin B is a Flavone (HY-N2424) derivative. Hyperwightin B can be isolated from Hypericum wightianum. Hyperwightin B does not exhibit significant neuroprotective activity against Corticosterone (HY-B1618)-induced neuronal injury.

Sampsonione P is an RXRα inhibitor isolated and extracted from Hypericum sampsonii. Sampsonione P inhibits RXRα transcriptional activity and can downregulate the expression of pro-inflammatory proteins such as iNOS and COX-2, thereby exerting anti-inflammatory effects. Sampsonione P has antitumor activity. Sampsonione P can be used for research on inflammatory diseases and cancer.

Uralione E is a naturally occurring polycyclic polyprenylated acylphloroglucinol (PPAP). Uralione E exhibits a protective effect against corticosterone (HY-B1618)-induced damage in PC12 cells. In a free fatty acid (FFA)-induced L02 cell model, Uralione E dose-dependently reduces intracellular lipid accumulation, downregulates the expression of FASN and CD36, and upregulates the expression of ACOX1 and PPARα. Uralione E can be used in studies related to neuronal cell damage, lipid metabolism, and non-alcoholic steatohepatitis.

Uralione D is a neuroprotective agent found in Hypericum uralum and Hypericum kouytchense. Uralione D exhibits cytotoxic activity against gastric cancer cells and protects against Corticosterone (HY-B1618)-induced damage in neuron-like cells. Uralione D is useful for research on depression, multidrug-resistant liver cancer, and gastric cancer.

Hypercohin K is a polycyclic polyprenylated acylphloroglucinol isolated from Hypericum henryi, containing a rare spiro-fused cyclopropane ring in its structure. Hypercohin K exhibits anti-inflammatory, antitumor, and AChE-enhancing activities. Hypercohin K reduces intracellular lipid accumulation by regulating lipid metabolism genes, and can inhibit NO production to exert anti-inflammatory effects. Hypercohin K can be used in research on non-alcoholic steatohepatitis and tumors.

Hypelodin A is a Hypelodin. Hypelodin A can be isolated from H. beanii. Hypelodin A can be used in research on colorectal cancer, breast cancer, and liver cancer.

Hypatulin A is a terpenoid compound found in the leaves of Hypericum patulum. Hypatulin A exhibits antibacterial activity against Bacillus subtilis. Hypatulin A can be used in research related to bacterial infections.

Sampsonione D is a Hypercohone. Sampsonione D is isolated from the aerial parts of Hypericum cohaerens. Sampsonione D inhibits Alpha-glucosidase, with an IC₅₀ of 116.0 μM against yeast Alpha-glucosidase. Sampsonione D is inactive against Acetylcholinesterase. Sampsonione D exhibits no anticancer activity against non-small cell lung cancer, leukemia, breast cancer, or colorectal adenocarcinoma.

Uralione I is a polycyclic polyprenylated acylphloroglucinol (PPAP) found in the whole plant of Hypericum uralum. Uralione I can be used for research on depression.

Sampsonione O is a neuroprotective agent. Sampsonione O is present in Hypericum species. Sampsonione O exerts neuroprotective effects against L-glutamic acid (HY-14608)-induced injury. Sampsonione O can be used for research on neuronal injury^[3]4].

Uralodin A is a polycyclic polyprenylated acylphloroglucinol (PPAP). Uralodin A exerts cytotoxic activity through its inhibitory effects on tumor cells. Uralodin A can be used for cancer-related research.

Uralodin B is a naturally occurring polycyclic polyprenylated acylphloroglucinol (PPAP) and is the C (30)-epimer of Uralodin C. It is found in the aerial parts of Hypericum henryi subsp. uraloides. Uralodin B exhibits cytotoxic activity against SGC7901 and HL-60 tumor cells. It is useful for research related to PPAP natural products and tumor cytotoxicity.

Attenuatumione H is a polycyclic polyprenylated acylphloroglucinol compound found in the whole plant of Hypericum attenuatum, and it exhibits antitumor activity. Attenuatumione H exerts cytotoxic effects on liver cancer cells and breast cancer cells. Attenuatumione H shows no significant inhibitory effect on LPS-induced NO production in macrophages and displays no significant cytotoxic activity against osteosarcoma cells. Attenuatumione H can be used in cancer research.

Hyperhenol B is a dearomatized isoprenylated acylphloroglucinol derivative that can be found in Hypericum henryi.