Hypericaceae Extract

Hyperwightin B is a natural flavonoid.

Hyperwightin D is a natural phenolic compound.

Hyperwightin E is a natural phenolic compound.

4a-Demethoxysampsone B is a natural phenolic compound.

Pruniflorone R is a natural xanthone.

3,6-Dihydroxy-1,7-dimethoxyxanthone is a natural xanthone.

1-Isomangostin hydrate is a semi-synthetic cyclized xanthone derivative of α-mangostin (HY-N0328), exhibiting weak cytotoxicity against HT-29 human colon cancer cells (ED₅₀ > 20 μM). 1-Isomangostin hydrate can be used in research on colon cancer and other tumors. The natural precursor of 1-isomangostin hydrate, α-mangostin, is derived from the stem of Cratoxylum cochinchinense (a plant of the Cratoxylum genus in the Clusiaceae family).

Sampsone B is a dihydrodibenzodioxinone-type antibacterial agent with a minimum inhibitory concentration (MIC) of ≥128 μg/mL against methicillin-resistant Staphylococcus aureus (MRSA). Sampsone B can be naturally extracted from the aerial parts (stems and leaves) of Hypericum sampsonii.

3-Isomangostin hydrate formate is a derivative of mangostin that can be isolated from Garcinia mangostana Linn. (Guttiferae).

4-Hydroxy-2,3-dimethoxyxanthone is an anti-inflammatory agent isolated from Hypericum oblongifolium (Hypericum oblongifolium Wall.).

Hyperxanthone is a pyranoxanthone compound isolated from Hypericum sampsonii Hance.

Toxyloxanthone B is a xanthone.

Hyperwightin C is a benzophenone glycoside. Hyperwightin C has not shown any significant neuroprotective effect.

Elodeoidileon A is an agonist for RXRα, that interacts with RXRα-LBD protein with a dissociation constant K_d of 5.85 μM. Elodeoidileon A promotes the expression of ATP-binding cassette transporter A1 (ABCA1). Elodeoidileon A reveals the potential in Alzheimer's disease research.

Spirohypertone B is a potent Tumor necrosis factor-α (TNF-α) inhibitor. Spirohypertone B protects L929 cells from death induced by co-incubation with TNF-α and Actinomycin D (HY-17559).

α-Glucosidase-IN-64 (compound 10) is a potent α-glucosidase inhibitor with an IC₅₀ value of 8.62 µM. α-Glucosidase-IN-64 is a polycyclic polyprenylated acylphloroglucinol that can be isolated from hypericum beanii.

Hyperelamine A (compound 5) is a polycyclic polyprenylated acylphloroglucinols (PPAPs). Hyperelamine A exhibits inhibitory activity against LPS-activated NO production in BV-2 cells via TLR-4/NF κB signaling.

1,4-O-Diferuloylsecoisolariciresinol (compound 7) is a nature product that could be isolated from Hypericum nagasawae. 1,4-O-Diferuloylsecoisolariciresinol can be used in research of cancer.

Hypercalin B is an antibacterial agent that can be isolated from the hexane and chloroform extracts of the plant Hypericum acmosepalum. Hypercalin B exhibits inhibitory activity against multidrug-resistant strains of Staphylococcus aureus, with a MIC range of 0.5-128 mg/L.