1,4-O-Diferuloylsecoisolariciresinol
1,4-O-Diferuloylsecoisolariciresinol (compound 7) is a nature product that could be isolated from Hypericum nagasawae. 1,4-O-Diferuloylsecoisolariciresinol can be used in research of cancer.
For research use only. We do not sell to patients.
- CAS No.: 56973-66-1
- Formula: C40H42O12
- Molecular Weight:714.75
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Description
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
12 μg/mL
Compound: 3
|
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
Cytotoxicity against human A549 cells after 48 hrs by SRB assay
|
[PMID: 18603435] |
| A549 | IC50 |
7.1 μM
Compound: 11b
|
Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human A549 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 21958542] |
| B16-F1 | IC50 |
12 μg/mL
Compound: 3
|
Cytotoxicity against mouse B16F1 cells after 48 hrs by SRB assay
Cytotoxicity against mouse B16F1 cells after 48 hrs by SRB assay
|
[PMID: 18603435] |
| B16-F10 | IC50 |
9.8 μM
Compound: 11b
|
Cytotoxicity against mouse B16F10 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against mouse B16F10 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 21958542] |
| COLO 205 | IC50 |
5.2 μg/mL
Compound: 10
|
Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay
Cytotoxicity against human COLO205 cells after 48 hrs by MTT assay
|
[PMID: 19606850] |
| HCT-15 | IC50 |
8.3 μM
Compound: 11b
|
Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human HCT15 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 21958542] |
| K562 | IC50 |
17.3 μg/mL
Compound: 10
|
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
|
[PMID: 19606850] |
| K562 | IC50 |
19.9 μg/mL
Compound: 10
|
Cytotoxicity against human doxorubicin-resistant K562 cells after 48 hrs by MTT assay
Cytotoxicity against human doxorubicin-resistant K562 cells after 48 hrs by MTT assay
|
[PMID: 19606850] |
| KB | IC50 |
14.1 μg/mL
Compound: 10
|
Cytotoxicity against human KB cells after 48 hrs by MTT assay
Cytotoxicity against human KB cells after 48 hrs by MTT assay
|
[PMID: 19606850] |
| MCF7 | IC50 |
5.9 μg/mL
Compound: 10
|
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
|
[PMID: 19606850] |
| SK-MEL-2 | IC50 |
10 μg/mL
Compound: 3
|
Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay
Cytotoxicity against human SK-MEL-2 cells after 48 hrs by SRB assay
|
[PMID: 18603435] |
| SK-MEL-2 | IC50 |
8.3 μM
Compound: 11b
|
Cytotoxicity against human SK-MEL-2 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SK-MEL-2 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 21958542] |
| SK-OV-3 | IC50 |
21.7 μM
Compound: 11b
|
Cytotoxicity against human SKOV3 cells after 48 hrs by sulforhodamine B assay
Cytotoxicity against human SKOV3 cells after 48 hrs by sulforhodamine B assay
|
[PMID: 21958542] |
Chemical Information
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CAS No. 56973-66-1
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Molecular Weight 714.75
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Formula C40H42O12
-
SMILES
COC(C=C1C[C@@H](COC(/C=C/C2=CC(OC)=C(C=C2)O)=O)[C@H](COC(/C=C/C3=CC(OC)=C(C=C3)O)=O)CC4=CC(OC)=C(C=C4)O)=C(C=C1)O
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Structure Classification
-
Initial Source
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)