Acylphloroglucinol, biyouyanagiol, biyouyanagin B, and related spiro-lactones from Hypericum chinense

  • J Nat Prod. 2009 Aug;72(8):1447-52. doi: 10.1021/np900109y.
Naonobu Tanaka  1 ,  Yoshiki Kashiwada ,  Sang Yong Kim ,  Waka Hashida ,  Michiko Sekiya ,  Yasumasa Ikeshiro ,  Yoshihisa Takaishi
Affiliations
  • 1. Graduate School of Pharmaceutical Sciences, University of Tokushima, Shomachi 1-78, Tokushima 770-8505, Japan.
PMID: 19606850 DOI: 10.1021/np900109y
Abstract

Biyouyanagiol (1), an acylphloroglucinol-related compound having a unique cyclopenta-1,3-dione moiety, was isolated from a Japanese traditional medicinal plant, Hypericum chinense, together with three new spiro-lactone-related derivatives, biyouyanagin B (2), 5,6-dihydrohyperolactone D (3), and 4-hydroxyhyperolactone D (4). Their structures were established on the basis of spectroscopic evidence. In a cytotoxicity assay against human Cancer cell lines including multidrug-resistant (MDR) Cancer cell lines, several compounds demonstrated enhanced cytotoxicity against MDR KB cells in the presence of colchicine.