1927024-53-0
Chemical Structure
Uralione E
- CAS No.: 1927024-53-0
- Formula:C38H50O5
- Molecular Weight:586.80
IUPAC Name: (2R,3aS,5S,6R,7R)-7-benzoyl-2-(2-hydroxypropan-2-yl)-6-methyl-5,9-bis(3-methylbut-2-en-1-yl)-6-(4-methylpent-3-en-1-yl)-2,3,4,5,6,7-hexahydro-8H-3a,7-methanocycloocta[b]furan-8,10-dione
InChIKey: GRLNXWQUZPCPMW-ZHHZAFRWSA-N
SMILES: O=C(C1=CC=CC=C1)[C@@]23[C@@](C)([C@H](C[C@]4(C(O[C@H](C4)C(C)(O)C)=C(C3=O)C/C=C(C)\C)C2=O)C/C=C(C)\C)CC/C=C(C)/C
Biological Activity: Uralione E is a naturally occurring polycyclic polyprenylated acylphloroglucinol (PPAP). Uralione E exhibits a protective effect against corticosterone (HY-B1618)-induced damage in PC12 cells. In a free fatty acid (FFA)-induced L02 cell model, Uralione E dose-dependently reduces intracellular lipid accumulation, downregulates the expression of FASN and CD36, and upregulates the expression of ACOX1 and PPARα. Uralione E can be used in studies related to neuronal cell damage, lipid metabolism, and non-alcoholic steatohepatitis[1][2].
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Uralione E | Uralione E is a naturally occurring polycyclic polyprenylated acylphloroglucinol (PPAP). Uralione E exhibits a protective effect against corticosterone (HY-B1618)-induced damage in PC12 cells. In a free fatty acid (FFA)-induced L02 cell model, Uralione E dose-dependently reduces intracellular lipid accumulation, downregulates the expression of FASN and CD36, and upregulates the expression of ACOX1 and PPARα. Uralione E can be used in studies related to neuronal cell damage, lipid metabolism, and non-alcoholic steatohepatitis. | |||||||||||||||||||||
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References
- [1]. Zhou ZB, et al. Polycyclic Polyprenylated Derivatives from Hypericum uralum: Neuroprotective Effects and Antidepressant-like Activity of Uralodin A. Journal of natural products. 2016 May 27;79(5):1231-40.
- [2]. Lu WJ, et al. Diverse Polycyclic Polyprenylated Acylphloroglucinol Congeners with Anti-Nonalcoholic Steatohepatitis Activity from Hypericum forrestii. J Nat Prod. 2021 Apr 23;84(4):1135-1148.
