1562672-80-3
Chemical Structure
Sampsonione P
- CAS No.: 1562672-80-3
- Formula:C33H42O5
- Molecular Weight:518.68
IUPAC Name: (2S,3aS,5R,7R)-9-benzoyl-2-(2-hydroxypropan-2-yl)-6,6-dimethyl-5,7-bis(3-methylbut-2-en-1-yl)-2,3,4,5,6,7-hexahydro-8H-3a,7-methanocycloocta[b]furan-8,10-dione
InChIKey: ZQSSRTNPNZIEOJ-VMAQZOGSSA-N
SMILES: O=C1[C@@]23C(O[C@@H](C3)C(C)(O)C)=C(C([C@@]1(C(C)([C@@H](C2)C/C=C(C)\C)C)C/C=C(C)\C)=O)C(C4=CC=CC=C4)=O
Biological Activity: Sampsonione P is an RXRα inhibitor isolated and extracted from Hypericum sampsonii. Sampsonione P inhibits RXRα transcriptional activity and can downregulate the expression of pro-inflammatory proteins such as iNOS and COX-2, thereby exerting anti-inflammatory effects. Sampsonione P has antitumor activity. Sampsonione P can be used for research on inflammatory diseases and cancer[1][2][3][4][5].
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Sampsonione P | Sampsonione P is an RXRα inhibitor isolated and extracted from Hypericum sampsonii. Sampsonione P inhibits RXRα transcriptional activity and can downregulate the expression of pro-inflammatory proteins such as iNOS and COX-2, thereby exerting anti-inflammatory effects. Sampsonione P has antitumor activity. Sampsonione P can be used for research on inflammatory diseases and cancer. | |||||||||||||||||||||
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References
- [1]. Shen X, et al. Programmable meroterpene synthesis. Nature communications. 2020 Jan 24;11(1):508.
- [2]. Tian WJ, et al. Hypersampsones S–W, new polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii. RSC advances. 2016 May 24;6(56):50887-94.
- [3]. Li Y, et al. Polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii Hance and their anti-inflammatory activity. Fitoterapia. 2023 Sep;169:105610. [Content Brief]
- [4]. Li D, et al. Hyperattenins A–I, bioactive polyprenylated acylphloroglucinols from Hypericum attenuatum Choisy. RSC advances. 2014 Dec 18;5(7):5277-87.
- [5]. Gao W, et al. Polyisoprenylated benzoylphloroglucinol derivatives from Hypericum scabrum. Fitoterapia. 2016 Dec;115:128-134.