Polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii Hance and their anti-inflammatory activity

  • Fitoterapia. 2023 Sep:169:105610. doi: 10.1016/j.fitote.2023.105610.
Yanzhen Li  1 ,  Mingqiang Wang  1 ,  Jianhui Su  1 ,  Yuanyuan Wang  1 ,  Zhongxiang Zhao  2 ,  Zhanghua Sun  3
Affiliations
  • 1. School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China.
  • 2. School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China. Electronic address: [email protected].
  • 3. School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou 510006, China; Guangdong Provincial Key Laboratory of Utilization and Conservation of Food and Medicinal Resources in Northern Region, Shaoguan University, Shaoguan 512005, China. Electronic address: [email protected].
PMID: 37451349 DOI: 10.1016/j.fitote.2023.105610
Abstract

Phytochemical investigation of Hypericum sampsonii Hance resulted in the isolation of thirty-five polycyclic polyprenylated acylphloroglucinols including six new ones (1, 3, 5, and 15-17). Their structures were elucidated by UV, IR, NMR, HRESIMS, and calculated ECD analysis. Some compounds were evaluated for their anti-inflammatory effects in LPS-induced RAW264.7 cells. Compounds 1 and 26 showed significant inhibitory effects on LPS-induced NO production, and markedly suppressed the protein expression of iNOS and COX-2 in LPS-activated RAW264.7 cells.

Keywords
Anti-inflammatory activity; Hypericum sampsonii Hance; Polycyclic polyprenylated acylphloroglucinols.
Products