Sampsonione D
Sampsonione D is a Hypercohone. Sampsonione D is isolated from the aerial parts of Hypericum cohaerens. Sampsonione D inhibits Alpha-glucosidase, with an IC50 of 116.0 μM against yeast Alpha-glucosidase. Sampsonione D is inactive against Acetylcholinesterase. Sampsonione D exhibits no anticancer activity against non-small cell lung cancer, leukemia, breast cancer, or colorectal adenocarcinoma.
For research use only. We do not sell to patients.
- CAS No.: 221289-42-5
- Formula: C38H48O4
- Molecular Weight:568.79
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
IC50 & Target
[1]|
α‑glucosidase 116.0 μM (IC50) |
In Vitro
Sampsonione D exhibits inhibitory activity against yeast alpha-glucosidase with an IC50 of 116.0 μM[1].
Sampsonione D (50 μM; 20 min) exhibits no acetylcholinesterase inhibitory activity at 50 μM[5].
Sampsonione D (48 h) exhibits no cytotoxic activity against HL-60, A-549, SMMC-7721, MCF-7, and SW480 cell lines with an IC50 > 40 μM[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:HL-60, A-549, SMMC-7721, MCF-7, SW480
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Concentration:Various concentrations
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Incubation Time:48 h
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Result:Showed no activity against HL-60, A-549, SMMC-7721, MCF-7, and SW480 cell lines with IC50 > 40 μM.
Chemical Information
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CAS No. 221289-42-5
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Molecular Weight 568.79
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Formula C38H48O4
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SMILES
O=C1[C@@]23[C@@](C(C)([C@@H](C3)C(C)=C)C)([H])C[C@@]4([H])C(C)([C@@]1(C([C@@](C2=O)(C4)C/C=C(C)/CC/C=C(C)\C)=O)C(C5=CC=CC=C5)=O)C
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Structure Classification
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Initial Source
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.
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Breast Cancer Modeling
Breast cancer is a heterogeneous cancer, and it has been distinguished into four subtypes: luminal A, luminal B, HER2-positive and basal-like. Molecular mutations, epigenetic alterations, hormone exposure and immune microenvironment are related to the progression of breast cancer.
Purity & Documentation
References
[2]. Li Y, et al. Polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii Hance and their anti-inflammatory activity. Fitoterapia. 2023 Sep;169:105610. [Content Brief]
[3]. Lin YL, et al. Polyprenylated phloroglucinol derivatives from Hypericum sampsonii. Helvetica chimica acta. 2003 Jun;86(6):2156-63. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Sampsonione D Related Classifications
HY-N21701 Related Classifications
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