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Art. -Nr.: HY-N21701

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Sampsonione D

Sampsonione D is a Hypercohone. Sampsonione D is isolated from the aerial parts of Hypericum cohaerens. Sampsonione D inhibits Alpha-glucosidase, with an IC₅₀ of 116.0 μM against yeast Alpha-glucosidase. Sampsonione D is inactive against Acetylcholinesterase. Sampsonione D exhibits no anticancer activity against non-small cell lung cancer, leukemia, breast cancer, or colorectal adenocarcinoma.

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CAS. Nr.: 221289-42-5
Formel: C₃₈H₄₈O₄
Molecular Weight:568.79

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Sampsonione D Chemical Structure

CAS. Nr.: 221289-42-5

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

^[1]

α‑glucosidase

116.0 μM (IC₅₀)

In Vitro

Carbohydrate MetabolismFungal InfectionAnti-cancerOthers

Carbohydrate Metabolism

Fungal Infection

Sampsonione D exhibits inhibitory activity against yeast alpha-glucosidase with an IC₅₀ of 116.0 μM^[1].

Anti-cancer

Sampsonione D (48 h) exhibits no cytotoxic activity against HL-60, A-549, SMMC-7721, MCF-7, and SW480 cell lines with an IC₅₀ > 40 μM^[5].

Others

Sampsonione D (50 μM; 20 min) exhibits no acetylcholinesterase inhibitory activity at 50 μM^[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[5]

Cell Line:

HL-60, A-549, SMMC-7721, MCF-7, SW480
Concentration:

Various concentrations
Incubation Time:

48 h
Result:

Showed no activity against HL-60, A-549, SMMC-7721, MCF-7, and SW480 cell lines with IC50 > 40 μM.

Related Protocols :

Breast Cancer Modeling

Chemical Information

CAS. Nr. 221289-42-5
Molecular Weight 568.79
Formel C₃₈H₄₈O₄
SMILES

O=C1[C@@]23[C@@](C(C)([C@@H](C3)C(C)=C)C)([H])C[C@@]4([H])C(C)([C@@]1(C([C@@](C2=O)(C4)C/C=C(C)/CC/C=C(C)\C)=O)C(C5=CC=CC=C5)=O)C
Structure Classification
- Terpenoids
- Other Terpenoids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Nguyen NH, et al. Bio-guided isolation of alpha-glucosidase inhibitory compounds from Vietnamese fruits: and studies. RSC advances. 2023 Nov 30;13(50):35408-35421.

[2]. Li Y, et al. Polycyclic polyprenylated acylphloroglucinols from Hypericum sampsonii Hance and their anti-inflammatory activity. Fitoterapia. 2023 Sep;169:105610. [Content Brief]

[3]. Lin YL, et al. Polyprenylated phloroglucinol derivatives from Hypericum sampsonii. Helvetica chimica acta. 2003 Jun;86(6):2156-63. [Content Brief]

[4]. Sriyatep T, et al. Cowabenzophenones A and B, two new tetracyclo [7.3. 3.33, 11.03, 7] tetradecane-2, 12, 14-trione derivatives, from ripe fruits of Garcinia cowa. Fitoterapia. 2014 Jan 1;92:285-9.

[5]. Liu X, et al. Hypercohones A–C, acylphloroglucinol derivatives with homo-adamantane cores from Hypericum cohaerens. Nat Prod Bioprospect. 2013 Sep 6;3(5):233–7.

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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