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Cat. No.: HY-N21704

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Sampsonione O

Sampsonione O is a neuroprotective agent. Sampsonione O is present in Hypericum species. Sampsonione O exerts neuroprotective effects against L-glutamic acid (HY-14608)-induced injury. Sampsonione O can be used for research on neuronal injury^[3]4].

For research use only. We do not sell to patients.

CAS No.: 1001232-23-0
Formula: C₃₃H₄₂O₅
Molecular Weight:518.68

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Sampsonione O Chemical Structure

CAS No.: 1001232-23-0

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
Chemical Information
Protocols (1)
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
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Biological Activity

Description

In Vitro

Sampsonione O (1 h) exhibits significant activity against L-glutamic acid (HY-14608)-induced neuroblastoma SK-N-SH cell injury, but shows no activity against oxygen-glucose deprivation-induced injury^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

Cell Viability Assay^[3]

View Protocol

Cell Line:

SK-N-SH
Concentration:

10 μmol/L (DMSO)
Incubation Time:

1 h (pre-incubation); 4 h (L-Glu co-incubation); 24 h (OGD incubation)
Result:

Increased the survival rate of SK-N-SH cells to 80.90% (mean OD 0.729) in the L-glutamic acid model.
Resulted in a survival rate of 57.80% (mean OD 0.904) in the oxygen-glucose deprivation model.

Chemical Information

CAS No. 1001232-23-0
Molecular Weight 518.68
Formula C₃₃H₄₂O₅
SMILES

O=C(C1=CC=CC=C1)[C@@]23C([C@@](C4=C(C[C@H](O4)C(C)(O)C)C2=O)(C[C@H](C3(C)C)C/C=C(C)\C)C/C=C(C)\C)=O
Structure Classification
- Terpenoids
- Other Terpenoids
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Protocols

All Animals and Diseases

Neurotoxicity Study
This protocol assesses in vitro neurotoxicity by combining neuronal viability, mitochondrial/metabolic activity, neurite outgrowth, and optional neuronal network function readouts. Calcein-AM or resazurin/PrestoBlue readouts estimate viable or metabolically active cells; βIII-tubulin immunofluorescence detects neuronal morphology and neurite networks; TMRE detects mitochondrial membrane potential; and MEA recordings detect functional changes in neuronal network activity.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sparling BA. Total Synthesis of Hyperforin. Harvard University; 2013.

[2]. FAN X, et al. Progress in the Study of the Chemical Composition and Biological Activity of Hypericum Attenuatum Choisy. Modernization of Traditional Chinese Medicine and Materia Medica——World Science and Technology.;27(6):1578-91.

[3]. Suo XY, et al. Two new polycyclic polyprenylated acylphloroglucinols derivatives from . Journal of Asian natural products research. 2021 Nov;23(11):1068-1076.

[4]. Dugay A, et al. Targeted Dereplication of H. patulum and H. hookeranium Extracts: Establishing MS/MS Fingerprints for the Identification of Polycyclic Polyprenylated Acylphloroglucinols. Molecules. 2025 Jun 10;30(12):2531.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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