country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-N21682

Copy Link Print Information

Adhumulone

Adhumulone is an α-acid derived from hops and a selective AKR1B10 inhibitor, with IC₅₀ values of 5.41-29.27 μM and K_i values of 3.27-16.79 μM against human AKR1B10. Adhumulone inhibits AKR1B10-mediated reduction of Farnesol (HY-Y0248A) as a competitive inhibitor, and it also suppresses the reduction of DL-Glyceraldehyde (HY-128748) and Farnesal substrates. Adhumulone is useful for research on ras-dependent malignancies.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 31769-65-0
分子式: C₂₁H₃₀O₅
分子量:362.46

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Adhumulone 構造式

CAS 番号: 31769-65-0

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

^[1]^[2]

AKR1B10

5.41-29.27 μM (IC₅₀)

AKR1B10

3.27-16.79 μM (Ki)

体外実験

Adhumulone (Compound 1) selectively inhibits recombinant human AKR1B10 when DL-Glyceraldehyde (HY-128748) is used as the substrate, with an IC₅₀ of 5.41 µM and a K_i value of 3.27 μM, while its activity against AKR1A1 and AKR1B1 is much weaker^[1].
Adhumulone acts as a competitive inhibitor of recombinant human AKR1B10-mediated reduction of Farnesol (HY-Y0248A), with an IC₅₀ of 29.27 µM and a K_i of 16.79 µM^[1].
Adhumulone (41c) is a major α-acid sensory metabolite in fresh Humulus lupulus L. hop pellets, with concentrations ranging from 5-15% across 75 commercial hop varieties^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 31769-65-0
分子量 362.46
分子式 C₂₁H₃₀O₅
SMILES

O=C(C(CC)C)C(C(O)=C1C/C=C(C)\C)=C(O)C(O)(C/C=C(C)\C)C1=O
Structure Classification
- Ketones, Aldehydes, Acids
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Seliger JM, et al. Selective Inhibition of Human AKR1B10 by n-Humulone, Adhumulone and Cohumulone Isolated from Humulus lupulus Extract. Molecules. 2018 Nov 21;23(11):3041.

[2]. Dresel M, et al. The Bitter Chemodiversity of Hops (Humulus lupulus L.). Journal of agricultural and food chemistry. 2016;64(41):7789-7799. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ