BPDA2
Based on 1 Customer Validation
BPDA2 is a highly selective and competitive active site SHP2 inhibitor with IC50s of 92.0 nM, 33.39 μM, 40.71 μM for SHP2, SHP1, SHP1B, respectively. DBDA2 downregulates mitogenic and cell survival signaling and RTK expression. BPDA2 suppresses SHP2 mediated signaling and breast cancer cell phenotypes.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.30%
- CAS 番号: 2907659-86-1
- 分子式: C24H30O5
- 分子量:398.49
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
BPDA2 (0.2-3.2 μM) inhibits basal activation of Akt and ERK1/2 in a concentration dependent manner[1].
BPDA2 (0.25-4.0 μM; for 10 days) suppresses the anchorage independent growth and cancer stem cell properties of breast cancer cells in a concentration dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:JIMT-1, MDA-MB468 cell
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Concentration:0.2, 0.4, 0.8, 1.6, 3.2 μM
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Incubation Time:
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Result:Inhibited basal activation of Akt and ERK1/2 in a concentration dependent manner.
化学情報
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CAS 番号 2907659-86-1
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性状 Solid
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分子量 398.49
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分子式 C24H30O5
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Color White to off-white
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SMILES
CCCCCCCCCOC1=CC=C(C=C1C(O)=O)C2=CC=C(C=C2)CC(O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
純度とドキュメンテーション
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データシート (264 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
BPDA2 関連分類
HY-152208 関連分類
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