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製品番号: HY-183288

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COX-2-IN-66

COX-2-IN-66 is a cyclooxygenase-2 (COX-2) inhibitor with an IC₅₀ of 8.43 μM. COX-2-IN-66 reduces release of pro-inflammatory cytokines IL-6 and TNF-α. COX-2-IN-66 exhibits acceptable cellular tolerability, with cytokine-modulating concentrations remaining below its cytotoxic threshold. COX-2-IN-66 can be used for the research of inflammation.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

分子式: C₂₃H₂₃NO₂
分子量:345.43

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

COX-2-IN-66 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target^[1]

COX-2

8.43 μM (IC₅₀)

COX-1

32.47 μM (IC₅₀)

IL-6

COX アイソフォーム固有の製品をすべて表示 :

Interleukin Related アイソフォーム固有の製品をすべて表示 :

TNF Receptor アイソフォーム固有の製品をすべて表示 :

体外実験

COX-2-IN-66 (Compound 35e) potently inhibits cell-free COX-2 enzymatic activity with an IC₅₀ of 8.43 μM^[1].
COX-2-IN-66 inhibits cell-free COX-1 enzymatic activity with an IC₅₀ of 32.47 μM, yielding a COX-1/COX-2 selectivity index of 3.85^[1].
COX-2-IN-66 (3.125-100 μM; 24 h) exhibits cytotoxicity in THP-1 macrophages with an IC₅₀ of 67.9 μM^[1].
COX-2-IN-66 (2.1-33.7 μM; 22 h) reduces IL-6 and TNF-α release in LPS (HY-D1056)-stimulated THP-1 macrophages with IC₅₀ values of 35.1 μM and 42.3 μM, respectively, under non-cytotoxic conditions^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Cytotoxicity Assay^[1]

Cell Line:

THP-1 macrophages
Concentration:

3.125, 6.25, 25, 50, 100 μM
Incubation Time:

24 h
Result:

Showed a cytotoxic IC₅₀ of 67.9 μM in THP-1 macrophages, which was higher than the concentrations required for cytokine modulation.

ELISA Assay^[1]

Cell Line:

LPS-stimulated THP-1 macrophages
Concentration:

2.1, 4.2, 8.4, 16.8, 33.7 μM; 35.1 μM
Incubation Time:

22 h
Result:

Reduced IL-6 and TNF-α release in a concentration-dependent manner, with estimated IC₅₀ values of 35.1 μM for IL-6 and 42.3 μM for TNF-α.
These concentrations were below the cytotoxic IC₅₀ in THP-1 cells.

化学情報

分子量 345.43
分子式 C₂₃H₂₃NO₂
SMILES

COC1=CC=C(C(C2=CC=C(C)C=C2)N3CCC4=C3C=CC=C4)C(O)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Pacheco JA, et al. Binding pose analysis and scaffold optimization of petasis products for selective COX-2 inhibition. Eur J Med Chem. Published online April 20, 2026. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

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Amount: USD 0.00

生物活性
- 製品説明
- IC₅₀ & Target
- 体外実験
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
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COX-2-IN-66

COX アイソフォーム固有の製品をすべて表示

Interleukin Related アイソフォーム固有の製品をすべて表示

TNF Receptor アイソフォーム固有の製品をすべて表示

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

COX-2-IN-66 関連分類

HY-183288 関連分類